Adagrasib and Digoxin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Adagrasib
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to P-gp substrates and an increased risk of P-gp substrates-related adverse effects
Interaction Deep Dive
Avoid concomitant use of adagrasib with P-gp substrates, where minimal concentration changes may lead to serious adverse reactions. Concomitant use of P-gp substrates with adagrasib increases exposure of P-gp substrates, which may increase the risk of adverse reactions related to these substrates. Concomitant use of 600 mg twice daily dose of adagrasib with digoxin (a P-gp substrate), the predicted increase in AUC and Cmax of digoxin is by 1.5-fold and 1.9-fold respectively1.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport by adagrasib
Literature reports
1 report — tap to read
a) Concomitant use of 600 mg twice daily dose of adagrasib with digoxin (a P-gp substrate), the predicted increase in AUC and Cmax of digoxin is by 1.5-fold and 1.9-fold respectively 1.
Common questions
Can I take Adagrasib and Digoxin together?
Increased exposure to P-gp substrates and an increased risk of P-gp substrates-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Adagrasib and Digoxin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Adagrasib or Digoxin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: KRAZATI(TM) oral tablets, adagrasib oral tablets. Mirati Therapeutics Inc (per FDA), San Diego, CA, 2024. DailyMed
Keep reading about Adagrasib
Keep reading about Digoxin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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