Aliskiren

Name: Aliskiren Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

51 interactions 133 cited references

Also sold as: Tekturna Tekturna®

About Aliskiren

Aliskiren is used alone or in combination with some medications to treat high blood pressure. Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently. High… Read the full Aliskiren drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Olmesartan Moexipril Sparsentan Ramipril Quinapril Olmesartan Medoxomil

22 Contraindicated 19 Major 10 Moderate

All (51) Contraindicated (22) Major (19) Moderate (10)

Major

Aliskiren Lenacapavir Oral Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details

Moderate

Aliskiren Amiloride Hyperkalemia Details Aliskiren Eplerenone Inspra Hyperkalemia Details Aliskiren Furosemide Disal Decreased furosemide exposure Details Aliskiren Levacetylleucine Aqneursa Increased P-gp inhibitor exposure and an increased risk of P-gp substrate-related adverse reactions Details Aliskiren Lomitapide Increased P-gp substrate exposure Details Aliskiren Potassium Glu-K® Hyperkalemia Details Aliskiren Rifampin Rifadin Reduced aliskiren plasma concentrations and exposure Details Aliskiren Spironolactone Aldactone Hyperkalemia Details Aliskiren Triamterene Dyrenium Hyperkalemia Details Aliskiren Furosemide Injection Disal Decreased furosemide exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.