Aliskiren and Furosemide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 10, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Furosemide
Aliskiren
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased furosemide exposure
Interaction Deep Dive
In 1 study, concurrent administration of aliskiren with furosemide resulted in reductions in furosemide AUC and Cmax of 17% and 27%, respectively. This change in furosemide exposure did not result in statistically significant differences in total urine volume or urinary sodium excretion over 24 hours, but a transient decrease in urine and urinary sodium excretion up to 12 hours were observed. Therefore, monitor diuretic effects of furosemide if these agents are coadministered1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) In heart failure patients, concurrent use of aliskiren 300 mg/day and furosemide 60 mg/day resulted in reductions in furosemide AUC and Cmax of 17% and 27%, respectively. This change in furosemide exposure did not result in statistically significant differences in total urine volume or urinary sodium excretion over 24 hours, but a transient decrease in urine and urinary sodium excretion up to 12 hours were observed 1.
Common questions
Can I take Aliskiren and Furosemide together?
Decreased furosemide exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aliskiren and Furosemide interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Aliskiren or Furosemide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Amturnide(TM) oral tablets, aliskiren amlodipine hydrochlorothiazide oral tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2013.
Keep reading about Furosemide
Keep reading about Aliskiren
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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