Alogliptin and Celiprolol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Alogliptin
Celiprolol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia
Interaction Deep Dive
Concomitant antidiabetic drugs and beta-blockers may lead to hypo- or hyperglycemia, or may obscure symptoms of hypoglycemia12. Tachycardia, but not other symptoms of hypoglycemia, such as dizziness and sweating, may be affected 6. Nonselective beta blockers can potentiate insulin-induced hypoglycemia and interfere with recovery of serum glucose levels. Worsening hyperglycemia may occur in patients with heart failure and diabetes 7. Increased frequency of glucose monitoring or dose adjustment of the antidiabetic agent may be required 12. Closely monitor for signs and symptoms of hypoglycemia with concurrent use, and if the beta-blocker is withdrawn, observe for loss of glycemic control 3.
Why it happens (mechanism)
Altered glucose metabolism and beta blockade
Literature reports
2 reports — tap to read
a) The choice of antihypertensive drug in elderly patients with diabetes who were taking either insulin or sulfonylureas had little effect on the risk of hypoglycemia, but after adjustment for other risk factors, the lowest risk was with cardioselective beta blockers and the highest with non-cardioselective beta blockers, with other antihypertensive drugs having intermediate results (N=13,559) 4.
b) Beta blockers, but not alpha blockade and ACE inhibitors, caused a deterioration in long-term glycemic control in patients with hypertension and non-insulin dependent diabetes. Some adverse effects on the lipid profile also occurred with beta blockade. These effects were especially apparent with propranolol. Concurrent use of an alpha blocker with the beta blocker prevented the deterioration due to beta blockade 5.
Common questions
Can I take Alogliptin and Celiprolol together?
Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Alogliptin and Celiprolol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Alogliptin or Celiprolol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (7)
- Product Information: TOUJEO(R) subcutaneous injection, insulin glargine subcutaneous injection. sanofi-aventis (per manufacturer), Bridgewater, NJ, 2015. DailyMed
- Product Information: AMARYL(R) oral tablets, glimepiride oral tablets. Sanofi-Aventis U.S. LLC (per FDA), Bridgewater, NJ, 2013. DailyMed
- Product Information: Glynase(R) PresTab(R) oral micronized tablets, glyburide oral micronized tablets. Pharmacia & Upjohn Co (per FDA), New York, NY, 2013. DailyMed
- Shorr RI, Ray WA, Daugherty JR, et al: Antihypertensives and the risk of serious hypoglycemia in older persons using insulin or sulfonylureas. JAMA 1997; 278:40-43. DOI
- Whitcroft IA, Thomas JM, Rawsthorne A, et al: Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics. Horm Metab Res Suppl 1990; 22:42-46.
- Product Information: TENORMIN(R) oral tablets, atenolol oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2012. DailyMed
- Product Information: COREG CR(R) extended-release oral capsules, carvedilol phosphate extended-release oral capsules. GlaxoSmithKline, Research Triangle Park, NC, 2011. DailyMed
Keep reading about Alogliptin
Keep reading about Celiprolol
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