Amifampridine

39 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Trospium / Xanomeline Methylphenidate Penicillin V Potassium Estramustine Diphenhydramine Injection

39 Major

All (39) Major (39)

Major

Amifampridine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of seizures Details Amifampridine Trospium / Xanomeline Cobenfy Explained Increased risk of seizures Details Amifampridine Alcaftadine Ophthalmic Lastacaft Increased risk of seizures Details Amifampridine Ampicillin Amcill® Increased risk of seizures Details Amifampridine Ampicillin Injection Omnipen-N® Increased risk of seizures Details Amifampridine Aclidinium Oral Inhalation Tudorza Increased risk of seizures Details Amifampridine Azelastine Nasal Spray Astelin® Nasal Spray Increased risk of seizures Details Amifampridine Azelastine Ophthalmic Optivar® Increased risk of seizures Details Amifampridine Atropine Ophthalmic Atropine Care 1% Increased risk of seizures Details Amifampridine Bepotastine Ophthalmic Bepreve Increased risk of seizures Details Amifampridine Butorphanol Injection Butorphic Increased risk of seizures Details Amifampridine Butorphanol Nasal Spray Stadol® NS Increased risk of seizures Details Amifampridine Chlorambucil Leukeran Increased risk of seizures Details Amifampridine Cyclopentolate Ophthalmic Akpentolate® Increased risk of seizures Details Amifampridine Cyclosporine Injection Atopica Increased risk of seizures Details Amifampridine Cyclosporine Ophthalmic Cequa Increased risk of seizures Details Amifampridine Diphenhydramine Injection Banophen Increased risk of seizures Details Amifampridine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of seizures Details Amifampridine Epinastine Ophthalmic Elestat® Increased risk of seizures Details Amifampridine Estradiol Delestrogen Increased risk of seizures Details Amifampridine Estradiol Topical Divigel Increased risk of seizures Details Amifampridine Estradiol Transdermal Patch Alora® Increased risk of seizures Details Amifampridine Estramustine Emcyt Increased risk of seizures Details Amifampridine Fentanyl Transdermal Patch Duragesic® Increased risk of seizures Details Amifampridine Hydromorphone Injection Dilaudid Increased risk of seizures Details Amifampridine Hydromorphone Rectal available generically Increased risk of seizures Details Amifampridine Ketotifen Alaway Increased risk of seizures Details Amifampridine Ketotifen Ophthalmic Alaway Increased risk of seizures Details Amifampridine Lindane Gamene® Increased risk of seizures Details Amifampridine Lithium Carbonate Lithobid Increased risk of seizures Details Amifampridine Mefenamic Acid Ponstel® Increased risk of seizures Details Amifampridine Methylphenidate Adhansia XR® Increased risk of seizures Details Amifampridine Methylphenidate Transdermal Patch Daytrana Increased risk of seizures Details Amifampridine Morphine Injection Astramorph® PF Increased risk of seizures Details Amifampridine Nalbuphine Injection Nubain® Increased risk of seizures Details Amifampridine Neostigmine Methylsulfate Bloxiverz Increased risk of seizures Details Amifampridine Olopatadine Pataday Increased risk of seizures Details Amifampridine Olopatadine Nasal Spray PATANASE Increased risk of seizures Details Amifampridine Penicillin V Potassium Beepen-VK® Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.