Amiodarone
141 interactions 9 explained in plain English
Also sold as:
Nexterone
Pacerone
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketoconazole Topical
Deuruxolitinib
Colchicine
Glasdegib
Galantamine
Miconazole Vaginal
Major
Amiodarone Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Amiodarone Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Amiodarone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Amiodarone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Amiodarone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Amiodarone Methylergonovine Methergine Increased methylergonovine exposure Details Amiodarone Metronidazole Flagyl An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Metronidazole Injection Flagyl An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Metronidazole Topical MetroCream® An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Mexiletine Mexitil® Increased antiarrhythmic levels Details Amiodarone Miconazole Buccal Oravig Increased amiodarone exposure Details Amiodarone Miconazole Topical Aloe Vesta Antifungal Increased amiodarone exposure Details Amiodarone Miconazole Vaginal Lagicam Increased amiodarone exposure Details Amiodarone Miconazole Aloe Vesta Antifungal Increased amiodarone exposure Details Amiodarone Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Amiodarone Moxifloxacin Avelox Increased risk of QT interval prolongation Details Amiodarone Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Amiodarone Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Amiodarone Nafarelin Nasal Spray Synarel Increased risk of QT prolongation Details Amiodarone Nafcillin Injection Unipen® Injection Reduced amiodarone exposure and reduced efficacy of amiodarone Details Amiodarone Nevirapine Viramune Reduced amiodarone exposure and reduced efficacy of amiodarone Details Amiodarone Nifedipine Adalat® Increased NIFEdipine exposure Details Amiodarone Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Ofloxacin Floxin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Amiodarone Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Amiodarone Ospemifene Osphena Increased ospemifene exposure and increased risk of adverse events DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.