Amiodarone and Ospemifene: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 9, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amiodarone
Ospemifene
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased ospemifene exposure and increased risk of adverse events
Interaction Deep Dive
The concomitant use of ospemifene (a CYP3A4 and CYP2C9 substrate) and a dual CYP3A4 and CYP2C9 inhibitor may increase the exposure of ospemifene. If ospemifene is used concomitantly with a CYP3A4 and CYP2C9 inhibitor, closely monitor ospemifene levels1 and adjust the ospemifene dosage as required.
Why it happens (mechanism)
Inhibition of CYP3A4- and CYP2C9-mediated metabolism of ospemifene
Common questions
Can I take Amiodarone and Ospemifene together?
Increased ospemifene exposure and increased risk of adverse events Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amiodarone and Ospemifene interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Amiodarone or Ospemifene need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: OSPHENA(TM) oral tablets, ospemifene. Shionogi Inc. (per manufacturer), Florham Park, NJ, 2013. DailyMed
Keep reading about Amiodarone
Keep reading about Ospemifene
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist