Amitriptyline
525 interactions 416 explained in plain English 1,325 cited references
Also sold as:
Elavil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Dronedarone
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Major
Amitriptyline Zotepine Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Zuclopenthixol Explained An increased risk of QT interval prolongation Details Amitriptyline Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Amitriptyline Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Amitriptyline Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Amitriptyline Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Amitriptyline Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Amitriptyline Aspirin Rectal Aspirin An increased risk of bleeding Details Amitriptyline Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Amitriptyline Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Amitriptyline Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Amitriptyline Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Amitriptyline Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Amitriptyline Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Amitriptyline Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Amitriptyline Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Amitriptyline Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Amitriptyline Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Amitriptyline Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Amitriptyline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Amitriptyline Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Amitriptyline Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Amitriptyline Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Amitriptyline Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Amitriptyline Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Amitriptyline Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Amitriptyline Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Amitriptyline Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Amitriptyline Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Amitriptyline Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Amitriptyline Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Amitriptyline Ketoconazole Topical Extina® Foam An increased risk for QT interval prolongation Details Amitriptyline Ketorolac Injection Acular An increased risk of bleeding Details Amitriptyline Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Amitriptyline Ketorolac Ophthalmic Acular An increased risk of bleeding Details Amitriptyline Lacosamide Injection Motpoly An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Amitriptyline Levofloxacin Injection Levaquin Increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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