Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references
Also sold as: Elavil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride
35 Contraindicated 421 Major 55 Moderate 14 Minor
All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Major

Amitriptyline Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Amitriptyline Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Amitriptyline Meloxicam Injection Alloxate An increased risk of bleeding Details Amitriptyline Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Amitriptyline Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Amitriptyline Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Amitriptyline Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Amitriptyline Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Amitriptyline Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Amitriptyline Nalbuphine Injection Nubain® Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Amitriptyline Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Amitriptyline Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Amitriptyline Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation, an increased risk of ventricular arrhythmias and potentiated cardiovascular effects Details Amitriptyline Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Amitriptyline Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Amitriptyline Abiraterone Acetate Abirtega Explained Increased exposure of amitriptyline Details Amitriptyline Abiraterone Acetate, Micronized Abirtega Explained Increased exposure of amitriptyline Details Amitriptyline Acenocoumarol Explained An increased risk of bleeding Details Amitriptyline Amprenavir Explained Increased tricyclic agent serum concentrations and potential toxicity (anticholinergic effects, sedation, confusion, cardiac arrhy... Details Amitriptyline Anisindione Explained An increased risk of bleeding Details Amitriptyline Arbutamine Explained Unreliable arbutamine test results Details Amitriptyline Arformoterol Brovana Explained An increased risk of cardiovascular excitation Details Amitriptyline Atomoxetine Atoncy Explained An increase in atomoxetine steady-state plasma concentrations Details Amitriptyline Belladonna Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Amitriptyline Belladonna Alkaloids Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Amitriptyline Bethanidine Explained Decreased antihypertensive effectiveness Details Amitriptyline Brimonidine Alphagan Explained Reduced brimonidine hypotensive effects Details Amitriptyline Cimetidine Tagamet Explained Amitriptyline toxicity (dry mouth, blurred vision, urinary retention) Details Amitriptyline Cinacalcet Explained Increased exposure of amitriptyline Details Amitriptyline Clobazam Onfi Explained Increased exposure of amitriptyline Details Amitriptyline Desmopressin DDAVP Explained Increased risk of water intoxication with hyponatremia Details Amitriptyline Desogestrel Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Diazepam Diastat Explained Psychomotor deficits (decreased reaction time, decreased vigilance) Details Amitriptyline Dicumarol Explained An increased risk of bleeding Details Amitriptyline Dienogest Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Diphenhydramine Banophen Explained Increased anticholinergic effects (dry mouth, urinary retention) Details Amitriptyline Disulfiram Antabuse An increased risk of a psychotic and confusional mental state Details Amitriptyline Drospirenone Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Ethinyl Estradiol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.