Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references

Also sold as: Elavil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride

35 Contraindicated 421 Major 55 Moderate 14 Minor

All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Moderate

Amitriptyline Ethynodiol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Fosamprenavir Lexiva Explained Increased tricyclic agent serum concentrations and potential toxicity (anticholinergic effects, sedation, confusion, cardiac arrhy... Details Amitriptyline Galantamine Razadyne Increased galantamine plasma concentrations Details Amitriptyline Gestodene Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Guanadrel Explained Decreased antihypertensive effectiveness Details Amitriptyline Guanethidine Explained Decreased antihypertensive effectiveness Details Amitriptyline Guanfacine Intuniv Decreased antihypertensive effectiveness Details Amitriptyline Levonorgestrel After banger Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Mestranol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Mirabegron Myrbetriq Explained Increased amitriptyline exposure Details Amitriptyline Nomegestrol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norethindrone Aygestin Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norgestimate Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norgestrel Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Paltusotine Palsonify Explained An increased risk of PR interval prolongation Details Amitriptyline Phenindione Explained An increased risk of bleeding Details Amitriptyline Phenprocoumon Explained An increased risk of bleeding Details Amitriptyline Rifapentine Priftin Explained Decreased amitriptyline efficacy Details Amitriptyline Ritonavir Norvir Explained Increased amitriptyline serum concentrations and potential toxicity (anticholinergic effects, sedation, confusion, cardiac arrhyth... Details Amitriptyline S-Adenosylmethionine Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline St John's Wort Explained Decreased effectiveness of amitriptyline and possible increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus,... Details Amitriptyline Terbinafine Lamisil Explained Increased exposure of amitriptyline Details Amitriptyline Valproic Acid Depakene® Explained Increased amitriptyline exposure Details Amitriptyline Warfarin Coumadin Explained An increased risk of bleeding Details Amitriptyline Abiraterone Abirtega Increased exposure of amitriptyline Details Amitriptyline Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Amitriptyline Diazepam Nasal Spray Valtoco Psychomotor deficits (decreased reaction time, decreased vigilance) Details Amitriptyline Diazepam Rectal Diastat Psychomotor deficits (decreased reaction time, decreased vigilance) Details Amitriptyline Diphenhydramine Injection Banophen Increased anticholinergic effects (dry mouth, urinary retention) Details Amitriptyline Diphenhydramine Topical Afterbite with Antihistamine Increased anticholinergic effects (dry mouth, urinary retention) Details Amitriptyline Levonorgestrel Intrauterine System Kyleena Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details

Minor

Amitriptyline Baclofen Fleqsuvy Explained Memory loss, loss of muscle tone Details Amitriptyline Chlorotrianisene Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Dienestrol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Diethylstilbestrol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Esterified Estrogens Menest Explained Possible attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Estradiol Delestrogen Possible attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Estriol Explained Possible attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Estrone Explained Possible attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Estropipate Ogen Explained Possible attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details

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