Asenapine Transdermal Patch

377 interactions 1 explained in plain English 412 cited references
Also sold as: Secuado Secuado®
About Asenapine Transdermal Patch

Asenapine transdermal patches are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain… Read the full Asenapine Transdermal Patch drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide Piperaquine Bepridil
15 Contraindicated 276 Major 86 Moderate
All (377) Contraindicated (15) Major (276) Moderate (86)

Major

Asenapine Transdermal Patch Dordaviprone An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Doxepin Prudoxin Increased doxepin exposure, an increased asenapine exposure, an increased risk of CNS depression and an increased risk of QT inter... Details Asenapine Transdermal Patch Doxylamine Aldex AN Increased risk of CNS depression Details Asenapine Transdermal Patch Droperidol An increased risk of QT interval prolongation and an increased risk of CNS depression Details Asenapine Transdermal Patch Duloxetine Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Asenapine Transdermal Patch Ebastine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Efavirenz An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Eliglustat Cerdelga Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Asenapine Transdermal Patch Enasidenib Idhifa Increased asenapine exposure Details Asenapine Transdermal Patch Encorafenib Braftovi Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Enoxacin Increased asenapine exposure Details Asenapine Transdermal Patch Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Eribulin Halaven Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Escitalopram Lexapro An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Esketamine Spravato Increased risk of sedation Details Asenapine Transdermal Patch Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Asenapine Transdermal Patch Famotidine Calmicid Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Felbamate Felbatol Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fentanyl Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Asenapine Transdermal Patch Fexinidazole An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fingolimod Gilenya Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Flecainide Tambocor® Increased flecainide exposure, an increased asenapine exposure, an increased risk of QT interval prolongation and an increased ris... Details Asenapine Transdermal Patch Flibanserin Addyi Increased risk of CNS depression Details Asenapine Transdermal Patch Fluconazole Diflucan Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fluoxetine RECONCILE Increased FLUoxetine exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fluvoxamine Increased asenapine exposure and an increased fluvoxaMINE exposure Details Asenapine Transdermal Patch Formoterol Perforomist Increased risk of QT interval prolongation and an increased risk of cardiovascular adverse effects Details Asenapine Transdermal Patch Foscarbidopa An increased risk of CNS depression Details Asenapine Transdermal Patch Foscarnet Foscavir Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fosfomycin Contepo An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Foslevodopa An increased risk of CNS depression Details Asenapine Transdermal Patch Fosphenytoin Cerebyx An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Fostemsavir Rukobia Increased risk of torsade de pointes Details Asenapine Transdermal Patch Gabapentin Gabarone An increased risk of respiratory depression and sedation Details Asenapine Transdermal Patch Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Asenapine Transdermal Patch Galantamine Razadyne Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Gatifloxacin Zymaxid Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Gefitinib Iressa Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Asenapine Transdermal Patch Gemifloxacin Factive Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.