Asenapine Transdermal Patch

377 interactions 1 explained in plain English 412 cited references

Also sold as: Secuado Secuado®

About Asenapine Transdermal Patch

Asenapine transdermal patches are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain… Read the full Asenapine Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide Piperaquine Bepridil

15 Contraindicated 276 Major 86 Moderate

All (377) Contraindicated (15) Major (276) Moderate (86)

Major

Asenapine Transdermal Patch Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Asenapine Transdermal Patch Lopinavir An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Loxapine Adasuve Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Asenapine Transdermal Patch Lumefantrine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Macimorelin Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Asenapine Transdermal Patch Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Mefloquine Lariam® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Meperidine Demerol Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Asenapine Transdermal Patch Methadone Diskets Increased risk of respiratory and CNS depression and an increased risk of QT prolongation Details Asenapine Transdermal Patch Methocarbamol Atmeksi An increased risk of CNS depression Details Asenapine Transdermal Patch Methotrimeprazine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Metronidazole Flagyl An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Mifepristone Korlym Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Milsaperidone An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Asenapine Transdermal Patch Mizolastine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Mobocertinib Exkivity An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Moricizine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Morphine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Asenapine Transdermal Patch Morphine Sulfate Liposome Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Asenapine Transdermal Patch Moxifloxacin Avelox Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Nalbuphine Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Nelfinavir Viracept Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Nilotinib An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Norfloxacin Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Nortriptyline An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Octreotide Bynfezia Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ofloxacin Floxin® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Olanzapine An increased risk of QT interval prolongation and an increased risk of CNS depression Details Asenapine Transdermal Patch Oliceridine Olinvyk An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Asenapine Transdermal Patch Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Asenapine Transdermal Patch Ondansetron An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Osilodrostat Isturisa Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Osimertinib Tagrisso Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Oxaliplatin Increased risk of QT-interval prolongation Details Asenapine Transdermal Patch Oxycodone Oxaydo Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Oxymorphone Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Ozanimod Additive effects on heart rate Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.