Avanafil and Boceprevir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Boceprevir
No brand names on recordAvanafil
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased avanafil clearance and increased avanafil plasma concentration
Interaction Deep Dive
Concomitant administration of boceprevir (a strong CYP3A4 inhibitor)2 and avanafil (a CYP3A4 substrate) may result in increased avanafil exposure and toxicity. Compared with the pharmacokinetics of avanafil alone, the administration of a single dose of avanafil 50 mg with ketoconazole 400 mg/day (also a strong CYP3A4 inhibitor) resulted in a 13-fold increase in AUC, 3-fold increase in Cmax, and a prolonged half-life of 9 hours for avanafil. Although not specifically studied with boceprevir, other strong CYP3A4 inhibitors would be expected to have similar effects. Boceprevir and avanafil should not be used concomitantly 1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of avanafil by boceprevir
Common questions
Can I take Avanafil and Boceprevir together?
Decreased avanafil clearance and increased avanafil plasma concentration Always confirm with your pharmacist or prescriber before making any change.
How serious is the Avanafil and Boceprevir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Avanafil or Boceprevir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: STENDRA(R) oral tablets, avanafil oral tablets. Metuchen Pharmaceuticals LLC (per FDA), Freehold, NJ, 2022. DailyMed
- Product Information: VICTRELIS(R) oral capsules, boceprevir oral capsules. Schering Corporation (per FDA), Whitehouse Station, NJ, 2012.
Keep reading about Boceprevir
Keep reading about Avanafil
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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