Bepridil and Relugolix: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relugolix
Bepridil
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
These two medicines can affect your heart rhythm, and taking them together isn't recommended. Both relugolix (Orgovyx) and bepridil can each stretch out a part of your heartbeat called the QT interval. When you take them together, that effect can add up, which in rare cases can lead to a dangerous irregular heartbeat.
The good news is this is easy to sort out. If you've been prescribed both, please don't stop anything on your own. Instead, reach out to your pharmacist or doctor. There are usually safer alternatives your care team can choose from.
Contraindicated combination due to additive QT prolongation. Both agents independently prolong the QT interval; concurrent use raises the risk of QTc prolongation and torsades de pointes.
- Mechanism: additive pharmacodynamic QT prolongation (neither is a prodrug; this is a PD, not PK, interaction).
- Direction: increased cardiac effect (enhanced QT prolongation).
- Evidence: theoretical, but severity on file is contraindicated.
- Onset: unspecified.
- Management: avoid co-administration. If both are truly needed, consider an alternative agent; otherwise ECG and electrolyte (K+, Mg2+) monitoring per institutional QT protocols.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Administering bepridil together with agents that prolong the QT interval is contraindicated1.
Why it happens (mechanism)
Additive QT interval prolongation
How to manage this interaction
The main step here is avoiding this combination. Because both drugs can prolong the QT interval, using them together is flagged as contraindicated.
- Keep taking your medicines as prescribed for now, and do not stop either one on your own.
- Contact your pharmacist or prescriber promptly to let them know you've been prescribed both.
- Your care team will typically choose an alternative for one of the drugs so you aren't on both together.
- Ask about heart-rhythm (ECG) checks or blood tests for potassium and magnesium if your team wants to monitor you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Bepridil and Relugolix together?
Relugolix and bepridil can both prolong the QT interval, and combining them is contraindicated; keep taking what you're prescribed but contact your pharmacist or doctor promptly so an alternative can be arranged. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bepridil and Relugolix interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Bepridil and Relugolix interaction managed?
The main step here is avoiding this combination. Because both drugs can prolong the QT interval, using them together is flagged as contraindicated. Keep taking your medicines as prescribed for now, and do not stop either one on your own. Contact your pharmacist or prescriber promptly to let them know you've been prescribed both. Your care team will typically choose an alternative for one of the dr… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Bepridil or Relugolix need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Vascor(R) bepridil HCl. McNeil Pharmaceutical, Spring House, PA, 2000.
Keep reading about Relugolix
Keep reading about Bepridil
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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