Bleomycin and Brentuximab Vedotin Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Brentuximab Vedotin Injection
Bleomycin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of pulmonary toxicity
Interaction Deep Dive
Due to the increased risk of pulmonary toxicity, concomitant use of bleomycin and brentuximab is contraindicated1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) During a clinical trial observing brentuximab with a combination regimen including bleomycin, an increased incidence rate of noninfectious pulmonary toxicity was observed when compared with historical data for adriamycin/bleomycin/vinblastine/dacarbazine combination therapy. Symptoms typically included cough and dyspnea. Interstitial infiltration and inflammation on CT and radiographs were evident. Most patients responded to corticosteroid treatment 1.
Common questions
Can I take Bleomycin and Brentuximab Vedotin Injection together?
Increased risk of pulmonary toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bleomycin and Brentuximab Vedotin Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Bleomycin or Brentuximab Vedotin Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ADCETRIS(TM) intravenous injection, brentuximab vedotin intravenous injection. Seattle Genetics, Inc. (per FDA), Bothell, WA, 2012. DailyMed
Keep reading about Brentuximab Vedotin Injection
Keep reading about Bleomycin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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