Capecitabine

98 interactions 501 cited references

Also sold as: Xeloda Xeloda®

About Capecitabine

Capecitabine is used in combination with other medications to treat breast cancer that has come back after treatment with other medications. It is also used alone to treat breast cancer that has not improved after treatment with other medications. Capecitabine is also used to treat colon or rectal cancer (cancer that b… Read the full Capecitabine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Measles Virus Vaccine, Live

10 Contraindicated 83 Major 3 Moderate 2 Minor

All (98) Contraindicated (10) Major (83) Moderate (3) Minor (2)

Contraindicated

Capecitabine Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Capecitabine Tegafur Increased antineoplastic toxicity Details Capecitabine Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Capecitabine Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Capecitabine Omeprazole Gastrobim Reduction in capecitabine efficacy Details Capecitabine Abrocitinib Cibinqo Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Capecitabine Allopurinol Injection Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Capecitabine Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Benznidazole Increased exposure of 5-fluorouracil Details Capecitabine Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Acenocoumarol Increased vitamin K antagonist exposure and an increased risk of bleeding Details Capecitabine Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Capecitabine Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Capecitabine Azanidazole Increased exposure of 5-fluorouracil Details Capecitabine Brivudine Increased exposure of 5-fluorouracil (active moiety of capecitabine) Details Capecitabine Carvedilol Coreg Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Cedazuridine Increased exposure of cytidine deaminase substrates and increased risk of toxicity Details Capecitabine Celecoxib Celebrex Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects Details Capecitabine Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Capecitabine Cimetidine Tagamet An increased risk of fluorouracil toxicity Details Capecitabine Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Dexlansoprazole Dexilant Reduction in capecitabine efficacy Details Capecitabine Diclofenac Aleve Arthritis Pain Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Capecitabine Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Esomeprazole Nexium Reduction in capecitabine efficacy Details Capecitabine Etrasimod Velsipity Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Etravirine Intelence Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Capecitabine Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Capecitabine Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details

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