Captopril

231 interactions 998 cited references
Also sold as: Capoten®
About Captopril

Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, and certain kidney and heart conditions. Read the full Captopril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Valsartan Colchicine Aliskiren Sacubitril Allopurinol Azathioprine
4 Contraindicated 62 Major 165 Moderate
All (231) Contraindicated (4) Major (62) Moderate (165)

Major

Captopril Posaconazole Noxafil Increased posaconazole exposure Details Captopril Potassium Glu-K® Hyperkalemia Details Captopril Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Captopril Pregabalin Bonqat Increased risk of angioedema Details Captopril Ranolazine Aspruzyo Increased ranolazine exposure and an increased risk of ranolazine-related adverse effects Details Captopril Repotrectinib Augtyro Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Captopril Sirolimus Felycin Increased risk of angioedema Details Captopril Spironolactone Aldactone Increased risk of hyperkalemia Details Captopril Tacrolimus Astagraf An increased risk of hyperkalemia Details Captopril Telmisartan Micardis Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Captopril Temsirolimus Torisel Increased risk of angioedema Details Captopril Triamterene Dyrenium Increased risk of hyperkalemia Details Captopril Trimethoprim Primsol Increased risk of hyperkalemia Details Captopril Venetoclax Venclexta Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Captopril Cyclosporine Injection Atopica Acute renal dysfunction, increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Captopril Cyclosporine Ophthalmic Cequa Acute renal dysfunction, increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Captopril Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Captopril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Captopril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Captopril Melphalan Injection Alkeran An increased risk of severe hypotension Details Captopril Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Captopril Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.