Captopril

Name: Captopril Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

231 interactions 998 cited references

Also sold as: Capoten®

About Captopril

Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, and certain kidney and heart conditions. Read the full Captopril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Valsartan Colchicine Aliskiren Sacubitril Allopurinol Azathioprine

4 Contraindicated 62 Major 165 Moderate

All (231) Contraindicated (4) Major (62) Moderate (165)

Contraindicated

Captopril Colchicine Colcrys Increased colchicine exposure and an increased risk of colchicine toxicity Details Captopril Aliskiren Tekturna An increased risk of hyperkalemia, renal impairment, and hypotension Details Captopril Sacubitril Increased risk of angioedema Details Captopril Valsartan Diovan Increased risk of angioedema and an increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal fun... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.