Captopril

231 interactions 998 cited references

Also sold as: Capoten®

About Captopril

Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, and certain kidney and heart conditions. Read the full Captopril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Valsartan Colchicine Aliskiren Sacubitril Allopurinol Azathioprine

4 Contraindicated 62 Major 165 Moderate

All (231) Contraindicated (4) Major (62) Moderate (165)

Moderate

Captopril Felbinac Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Fepradinol Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Feprazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Floctafenine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Flufenamic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Glimepiride Amaryl An increased risk of hypoglycemia Details Captopril Glipizide Glucotrol An increased risk of hypoglycemia Details Captopril Glyburide DiaBeta® An increased risk of hypoglycemia Details Captopril Gold Sodium Thiomalate Nitritoid reactions (facial flushing, nausea, vomiting, and hypotension) Details Captopril Hydrochlorothiazide Inzirqo Reduction of blood pressure Details Captopril Hydroflumethiazide Reduction of blood pressure Details Captopril Ibuprofen Addaprin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Icatibant Firazyr Reduced captopril effectiveness Details Captopril Indapamide Reduction of blood pressure Details Captopril Indomethacin Indocin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Insulin Afrezza An increased risk of hypoglycemia Details Captopril Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Captopril Insulin Bovine An increased risk of hypoglycemia Details Captopril Insulin Degludec Tresiba An increased risk of hypoglycemia Details Captopril Insulin Detemir Levemir An increased risk of hypoglycemia Details Captopril Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Captopril Insulin Glulisine Apidra An increased risk of hypoglycemia Details Captopril Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Captopril Ketoprofen Actron® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Ketorolac Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Lanthanum Carbonate Fosrenol Reduced bioavailability of ACE inhibitors Details Captopril Linagliptin Tradjenta An increased risk of hypoglycemia Details Captopril Liraglutide Saxenda An increased risk of hypoglycemia Details Captopril Lixisenatide An increased risk of hypoglycemia Details Captopril Lornoxicam Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Loxoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Lumiracoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Magaldrate Decreased captopril effectiveness Details Captopril Magnesium Carbonate Decreased captopril effectiveness Details Captopril Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased captopril effectiveness Details Captopril Magnesium Oxide Mag-Ox 400 Decreased captopril effectiveness Details Captopril Magnesium Trisilicate Decreased captopril effectiveness Details Captopril Ma Huang Reduced effectiveness of angiotensin converting enzyme inhibitors Details

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