Captopril

231 interactions 998 cited references
Also sold as: Capoten®
About Captopril

Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, and certain kidney and heart conditions. Read the full Captopril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Captopril Meclofenamate Meclodium® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Mefenamic Acid Ponstel® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Meloxicam Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Metformin Fortamet® An increased risk of hypoglycemia Details Captopril Methyclothiazide Reduction of blood pressure Details Captopril Metolazone Reduction of blood pressure Details Captopril Miglitol Glyset® An increased risk of hypoglycemia Details Captopril Morniflumate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Nabumetone Relafen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Naproxen Aleve Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Nateglinide Starlix® An increased risk of hypoglycemia Details Captopril Nepafenac Ilevro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Nesiritide Increase in symptomatic hypotension Details Captopril Niflumic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Nimesulide Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Nimesulide Beta Cyclodextrin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Oxaprozin Coxanto Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Oxyphenbutazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Parecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Phenylbutazone Equi-Phar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Piketoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Pioglitazone Actos An increased risk of hypoglycemia Details Captopril Piretanide Postural hypotension (first dose) Details Captopril Piroxicam Feldene Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Polythiazide Reduction of blood pressure Details Captopril Pramlintide Symlin An increased risk of hypoglycemia Details Captopril Pranoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Proglumetacin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Propionic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Propyphenazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Proquazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Quinethazone Reduction of blood pressure Details Captopril Repaglinide Prandin® An increased risk of hypoglycemia Details Captopril Rofecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Rosiglitazone Avandia® An increased risk of hypoglycemia Details Captopril Salicylic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Salsalate Disalcid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Saxagliptin Onglyza An increased risk of hypoglycemia Details Captopril Semaglutide Ozempic An increased risk of hypoglycemia Details Captopril Sitagliptin Brynovin An increased risk of hypoglycemia Details

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