Captopril

231 interactions 998 cited references

Also sold as: Capoten®

About Captopril

Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, and certain kidney and heart conditions. Read the full Captopril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Valsartan Colchicine Aliskiren Sacubitril Allopurinol Azathioprine

4 Contraindicated 62 Major 165 Moderate

All (231) Contraindicated (4) Major (62) Moderate (165)

Moderate

Captopril Sodium Salicylate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Sulindac Clinoril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Captopril Tenoxicam Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Tiaprofenic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Tolazamide Tolinase® An increased risk of hypoglycemia Details Captopril Tolbutamide Orinase® An increased risk of hypoglycemia Details Captopril Tolfenamic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Tolmetin Tolectin 600 Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Torsemide Soaanz Postural hypotension (first dose) Details Captopril Trichlormethiazide Reduction of blood pressure Details Captopril Valdecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Xipamide Reduction of blood pressure Details Captopril Yohimbine Reduced angiotensin converting enzyme inhibitor effectiveness Details Captopril Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Captopril Exenatide Injection Bydureon An increased risk of hypoglycemia Details Captopril Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Captopril Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Captopril Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Captopril Ketorolac Injection Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Ketorolac Nasal Spray Sprix Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Ketorolac Ophthalmic Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Captopril Lanthanum Fosrenol® Reduced bioavailability of ACE inhibitors Details Captopril Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Captopril Lixisenatide Injection Adlyxin® An increased risk of hypoglycemia Details Captopril Meloxicam Injection Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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