Chloroquine

332 interactions 586 cited references

Also sold as: Aralen®

About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole

14 Contraindicated 294 Major 23 Moderate 1 Minor

All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Nelfinavir Viracept Increased risk of QT-interval prolongation Details Chloroquine Nilotinib An increased risk of QT interval prolongation Details Chloroquine Norfloxacin An increased risk of QT interval prolongation Details Chloroquine Nortriptyline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Chloroquine Olanzapine Increased risk of QT-interval prolongation Details Chloroquine Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Chloroquine Ondansetron An increased risk of QT interval prolongation Details Chloroquine Osilodrostat Isturisa Increased risk of QT interval prolongation Details Chloroquine Osimertinib Tagrisso Increased risk of QT interval prolongation Details Chloroquine Oxaliplatin Increased risk of QT-interval prolongation Details Chloroquine Ozanimod Additive effects on heart rate Details Chloroquine Pacritinib Vonjo® An increased risk of QT interval prolongation Details Chloroquine Paliperidone Erzofri An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Panobinostat Farydak Increased risk of QT interval prolongation Details Chloroquine Papaverine Pavacot® Increased risk of QT-interval prolongation Details Chloroquine Paroxetine Paxil Increased risk of QT-interval prolongation Details Chloroquine Pasireotide Signifor Increased risk of QT prolongation Details Chloroquine Pazopanib Votrient An increased risk of QT interval prolongation Details Chloroquine Pentamidine NebuPent An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Perphenazine Increased risk of QT-interval prolongation Details Chloroquine Phenobarbital Fidoquel An increased risk of QT interval prolongation Details Chloroquine Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Chloroquine Pioglitazone Actos Hypoglycemia Details Chloroquine Pirmenol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Pitolisant Wakix Increased risk of QT interval prolongation Details Chloroquine Pixantrone Increased exposure of CYP2C8 substrates Details Chloroquine Ponesimod Ponvory An increased risk of QT interval prolongation Details Chloroquine Posaconazole Noxafil An increased risk of QT interval prolongation Details Chloroquine Prajmaline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Pramlintide Symlin Hypoglycemia Details Chloroquine Primidone Mysoline An increased risk of QT interval prolongation Details Chloroquine Probucol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Procainamide Procan® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Prochlorperazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Propafenone Rythmol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Protriptyline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Quetiapine Seroquel An increased risk of QT interval prolongation Details Chloroquine Quinidine Cardioquin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.