Clofazimine

85 interactions 7 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Oxaliplatin Injection Famotidine Brexpiprazole Dofetilide Foscarnet Injection

83 Major 2 Moderate

All (85) Major (83) Moderate (2)

Major

Clofazimine Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Clofazimine Felbamate Felbatol An increased risk of QT interval prolongation Details Clofazimine Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Clofazimine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Clofazimine Flecainide Tambocor® An increased risk of QT interval prolongation Details Clofazimine Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Clofazimine Fostemsavir Rukobia Increased risk of torsade de pointes Details Clofazimine Galantamine Razadyne An increased risk of QT interval prolongation Details Clofazimine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Clofazimine Gemifloxacin Factive An increased risk of QT interval prolongation Details Clofazimine Goserelin Implant Zoladex An increased risk of QT interval prolongation Details Clofazimine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Clofazimine Granisetron Injection Granisol An increased risk of QT interval prolongation Details Clofazimine Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Clofazimine Hydroxychloroquine Plaquenil An increased risk of QT interval prolongation Details Clofazimine Ivabradine Corlanor An increased risk of QT interval prolongation Details Clofazimine Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Clofazimine Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and an increased risk of QT interval prolon... Details Clofazimine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Clofazimine Levofloxacin Levaquin An increased risk of QT interval prolongation Details Clofazimine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Clofazimine Loperamide Diamode Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Clofazimine Lumateperone Caplyta Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Clofazimine Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Clofazimine Mefloquine Lariam® An increased risk of QT interval prolongation Details Clofazimine Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Clofazimine Metronidazole Flagyl An increased risk of QT interval prolongation Details Clofazimine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Clofazimine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Clofazimine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Clofazimine Mitapivat Aqvesme Increased mitapivat exposure Details Clofazimine Moxifloxacin Avelox An increased risk of QT interval prolongation Details Clofazimine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Clofazimine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Clofazimine Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Clofazimine Nifedipine Adalat® Increased NIFEdipine exposure Details Clofazimine Octreotide Bynfezia An increased risk of QT interval prolongation Details Clofazimine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Clofazimine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Clofazimine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.