Clonidine Transdermal Patch

250 interactions 717 cited references

Also sold as: Catapres Catapres-TTS®

About Clonidine Transdermal Patch

Transdermal clonidine is used alone or in combination with other medications to treat high blood pressure. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. It works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the… Read the full Clonidine Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Phenelzine Tranylcypromine Verapamil Dibenzepin Dextroamphetamine

3 Contraindicated 67 Major 179 Moderate 1 Minor

All (250) Contraindicated (3) Major (67) Moderate (179) Minor (1)

Contraindicated

Clonidine Transdermal Patch Isocarboxazid Marplan An increased risk of hypertension, headache, and related symptoms Details Clonidine Transdermal Patch Phenelzine Nardil An increased risk of hypertensive crisis Details Clonidine Transdermal Patch Tranylcypromine Parnate Increased risk of hypertensive reaction, including intracerebral hemorrhage Details

Major

Clonidine Transdermal Patch Acebutolol Sectral® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Amineptine An increased risk of high blood pressure and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Amitriptyline Elavil Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Amitriptylinoxide An increased risk of high blood pressure and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Amlodipine Amvaz® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Amoxapine Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Amphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Clonidine Transdermal Patch Aranidipine An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Atenolol Tenormin An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Bepridil An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Betaxolol Betoptic S An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Bevantolol Increased risk of sinus bradycardia; exaggerated clonidine withdrawal response (acute hypertension) Details Clonidine Transdermal Patch Bisoprolol Zebeta® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Carteolol An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Carvedilol Coreg An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Celiprolol An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Ceritinib Zykadia Increased risk of bradycardia Details Clonidine Transdermal Patch Cilnidipine An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Clevidipine An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Clomipramine Anafranil Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Crizotinib Xalkori An increased risk of bradycardia Details Clonidine Transdermal Patch Desipramine Norpramin Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Dextroamphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Clonidine Transdermal Patch Dibenzepin An increased risk of high blood pressure and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Digoxin Cardoxin® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Dilevalol Increased risk of sinus bradycardia; exaggerated clonidine withdrawal response (acute hypertension) Details Clonidine Transdermal Patch Diltiazem Cardizem An increased risk of worsen sinus node dysfunction and atrioventricular node conduction and an increased risk of bradycardia and A... Details Clonidine Transdermal Patch Dothiepin Decreased antihypertensive effectiveness Details Clonidine Transdermal Patch Doxepin Prudoxin Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Esmolol Brevibloc An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Felodipine Plendil® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Imipramine Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Transdermal Patch Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia, which may sometimes be followed by hyperglycemia, an increased risk of blunted recognition of h... Details Clonidine Transdermal Patch Iobenguane I 131 Azedra Inaccurate dosimetry calculations or reduced efficacy Details Clonidine Transdermal Patch Isradipine DynaCirc® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Labetalol Normodyne® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Transdermal Patch Landiolol Attenuated landiolol heart rate lowering effects Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.