Drug Interaction Report

Clonidine Transdermal Patch and Dilevalol: Interaction Details

A pharmacist-reviewed analysis of the Clonidine Transdermal Patch and Dilevalol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Clonidine Transdermal Patch

Catapres Catapres-TTS®
+

Dilevalol

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 250 documented Clonidine Transdermal Patch interactions, 67 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of sinus bradycardia; exaggerated clonidine withdrawal response (acute hypertension)

Interaction Deep Dive

Concomitant administration of clonidine with beta-blocking agents, such as dilevalol, may increase the risk of sinus bradycardia. Therefore, heart rate should be monitored when clonidine and dilevalol are given concurrently. Patients to be withdrawn from clonidine who are concomitantly receiving a beta blocking agent should be withdrawn from the beta blocker several days before the gradual discontinuation of clonidine2. Abrupt withdrawal of clonidine while receiving a beta blocker may exaggerate the rebound hypertension due to unopposed alpha stimulation 1345. In the case of a hypertensive crisis following discontinuation of clonidine, IV phentolamine or oral clonidine can be used to reverse the excessive rise in blood pressure 2. Patients to be withdrawn from clonidine who are concomitantly receiving a beta blocking agent should be monitored carefully for hypertension.

Why it happens (mechanism)

Increased risk of sinus bradycardia; unopposed alpha adrenergic stimulation

Common questions

Can I take Clonidine Transdermal Patch and Dilevalol together?

Increased risk of sinus bradycardia; exaggerated clonidine withdrawal response (acute hypertension) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Clonidine Transdermal Patch and Dilevalol interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Clonidine Transdermal Patch or Dilevalol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (5)

  1. Bailey RR & Neale TJ: Rapid clonidine withdrawal with blood pressure overshoot exaggerated by beta-blockade. Br Med J 1976; 1:942-943. PubMed
  2. Product Information: CATAPRES oral tablet, clonidine hydrochloride oral tablet. Boehringer Ingelheim Promeco SA de CV, Mexico, Mexico, 2010. DailyMed
  3. Cummings DM & Vlasses PH: Antihypertensive drug withdrawal syndrome. Drug Intell Clin Pharm 1982; 16:817-822. PubMed
  4. Lilja M, Jounela AJ, Juustila HJ, et al: Abrupt and gradual change from clonidine to beta blockers in hypertension. Acta Med Scand 1982; 211:375-380. DOI
  5. Rosenthal T, Rabinowitz B, Boichis H, et al: Use of labetalol in hypertensive patients during discontinuation of clonidine therapy. Eur J Clin Pharmacol 1981; 20:237-240. PubMed
Was this write-up helpful?
Clonidine Transdermal Patch

Keep reading about Clonidine Transdermal Patch

All Clonidine Transdermal Patch interactions (250) Clonidine Transdermal Patch drug information
Also serious with: Isocarboxazid Phenelzine Tranylcypromine Verapamil
Dilevalol

Keep reading about Dilevalol

All Dilevalol interactions (10)
Also serious with: Indacaterol Oral Inhalation

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.