Colesevelam

49 interactions 77 cited references

Also sold as: Welchol WelChol®

About Colesevelam

A bile acid sequestrant medication used to lower cholesterol and fatty substances in the blood and help control blood sugar in type 2 diabetes. Read the full Colesevelam drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bezafibrate Deferasirox Desogestrel Dienogest Drospirenone Elafibranor

29 Major 19 Moderate 1 Minor

All (49) Major (29) Moderate (19) Minor (1)

Major

Colesevelam Bezafibrate Decreased bezafibrate efficacy Details Colesevelam Deferasirox Exjade Decreased deferasirox concentrations Details Colesevelam Desogestrel Decreased contraceptive effectiveness Details Colesevelam Dienogest Decreased contraceptive effectiveness Details Colesevelam Drospirenone Decreased contraceptive effectiveness Details Colesevelam Elafibranor Iqirvo Reduced elafibranor exposure and reduced efficacy of elafibranor Details Colesevelam Estradiol Delestrogen Decreased contraceptive effectiveness Details Colesevelam Ethinyl Estradiol Decreased contraceptive effectiveness Details Colesevelam Ethynodiol Decreased contraceptive effectiveness Details Colesevelam Ezetimibe Zetia Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Colesevelam Fenofibrate Antara Reduced fenofibric acid effectiveness and reduced absorption of fenofibrate Details Colesevelam Fenofibric Acid Fibricor Reduced fenofibric acid effectiveness and reduced absorption of fenofibrate Details Colesevelam Gestodene Decreased contraceptive effectiveness Details Colesevelam Levonorgestrel After banger Decreased contraceptive effectiveness Details Colesevelam Linerixibat Reduced exposure of linerixibat and reduced efficacy of linerixibat Details Colesevelam Lomitapide Reduced lomitapide exposure Details Colesevelam Mestranol Decreased contraceptive effectiveness Details Colesevelam Mycophenolate Mofetil Reduced exposure of mycophenolic acid (MPA) and reduced efficacy of mycophenolate mofetil Details Colesevelam Mycophenolic Acid Myfortic Reduced mycophenolic acid or mycophenolic sodium exposure Details Colesevelam Nomegestrol Decreased contraceptive effectiveness Details Colesevelam Norethindrone Aygestin Decreased contraceptive effectiveness Details Colesevelam Norgestimate Decreased contraceptive effectiveness Details Colesevelam Norgestrel Decreased contraceptive effectiveness Details Colesevelam Pravastatin Pravachol Reduced exposure to pravastatin Details Colesevelam Seladelpar Reduced seladelpar exposure and reduced efficacy of seladelpar Details Colesevelam Taurursodiol Reduced exposure of taurursodiol Details Colesevelam Estradiol Topical Divigel Decreased contraceptive effectiveness Details Colesevelam Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Colesevelam Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details

Moderate

Colesevelam Cholic Acid Decreased efficacy of cholic acid Details Colesevelam Cyclosporine Atopica Decreased cycloSPORINE exposure and plasma concentrations Details Colesevelam Diltiazem Cardizem Decreased diltiazem bioavailability Details Colesevelam Estetrol Decreased estetrol and drospirenone exposure Details Colesevelam Glimepiride Amaryl Decreased glimepiride exposure Details Colesevelam Glipizide Glucotrol Decreased glipiZIDE exposure Details Colesevelam Glyburide DiaBeta® Decreased glyBURIDE exposure and plasma concentrations Details Colesevelam Levothyroxine Ermeza Reduced levothyroxine exposure and reduced efficacy of levothyroxine Details Colesevelam Liothyronine Cytomel Decreased effectiveness of liothyronine Details Colesevelam Maralixibat Livmarli Reduced exposure and efficacy of maralixibat Details Colesevelam Metformin Fortamet® Increased exposure to extended-release metformin Details

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