Colesevelam and Seladelpar: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Colesevelam
Seladelpar
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced seladelpar exposure and reduced efficacy of seladelpar
Interaction Deep Dive
Coadministration of seladelpar and bile acid sequestrants may reduce seladelpar exposure and may also reduce efficacy of seladelpar. Administer seladelpar at least 4 hours before or 4 hours after taking bile acid sequestrants, or at as great an interval as possible1.
Why it happens (mechanism)
Reduced absorption of seladelpar
Common questions
Can I take Colesevelam and Seladelpar together?
Reduced seladelpar exposure and reduced efficacy of seladelpar Always confirm with your pharmacist or prescriber before making any change.
How serious is the Colesevelam and Seladelpar interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Colesevelam or Seladelpar need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIVDELZI® oral capsules, seladelpar oral capsules. Gilead Sciences, Inc. (Per Manufacturer), Foster City, CA, 2026. DailyMed
Keep reading about Colesevelam
Keep reading about Seladelpar
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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