Dacomitinib and Oliceridine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Oliceridine
Dacomitinib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased oliceridine exposure and an increased or prolonged opioid effects
Interaction Deep Dive
Coadministration of oliceridine (a CYP2D6 substrate) and a strong CYP2D6 inhibitor can increase oliceridine exposure, resulting in increased or prolonged opioid effects. If concomitant use is necessary in patients taking strong CYP2D6 inhibitor, consider less frequent dosing of oliceridine and monitor patients closely for respiratory depression and sedation at frequent intervals and subsequent doses based on the patient's severity of pain and response to treatment. If a CYP2D6 inhibitor is discontinued, consider increasing the dose of oliceridine until stable drug effects are achieved and monitor for signs of opioid withdrawal1.
Why it happens (mechanism)
Inhibition of CYP2D6-mediated metabolism of oliceridine
Common questions
Can I take Dacomitinib and Oliceridine together?
Increased oliceridine exposure and an increased or prolonged opioid effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dacomitinib and Oliceridine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dacomitinib or Oliceridine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: OLINVYK® intravenous injection, oliceridine intravenous injection. Trevena Inc (per FDA), Chesterbrook, PA, 2026. DailyMed
Keep reading about Oliceridine
Keep reading about Dacomitinib
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