Oliceridine

57 interactions 5 explained in plain English
Also sold as: Olinvyk
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Oliceridine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details Oliceridine Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Oliceridine Sertraline Explained Increased oliceridine exposure, and an increased risk of serotonin syndrome Details Oliceridine Buprenorphine Belbuca Explained Reduced analgesic effect of oliceridine and an increased risk of serotonin syndrome Details Oliceridine Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oliceridine Aripiprazole Injection Abilify An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Oliceridine Asenapine Transdermal Patch Secuado An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Oliceridine Abiraterone Abirtega Increased oliceridine exposure and an increased or prolonged opioid effects Details Oliceridine Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oliceridine Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oliceridine Bexarotene Targretin Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Bexarotene Topical Targretin Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Brigatinib Alunbrig Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Brivaracetam Briviact Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Brivaracetam Injection Briviact Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Butorphanol Injection Butorphic Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression and reduced anal... Details Oliceridine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression and reduced anal... Details Oliceridine Cetirizine Injection Aller-Tec An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Oliceridine Cetirizine Ophthalmic Zerviate An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Oliceridine Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oliceridine Dacomitinib Vizimpro Increased oliceridine exposure and an increased or prolonged opioid effects Details Oliceridine Darolutamide Nubeqa Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Dexamethasone Injection Decadron Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Diazepam Nasal Spray Valtoco An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Oliceridine Diazepam Rectal Diastat An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Oliceridine Diphenhydramine Injection Banophen Increased risk for hypotension, profound sedation, respiratory depression, coma, and death, and an increased risk of urinary reten... Details Oliceridine Diphenhydramine Topical Afterbite with Antihistamine Increased risk for hypotension, profound sedation, respiratory depression, coma, and death, and an increased risk of urinary reten... Details Oliceridine Dolasetron Anzemet Increased risk of serotonin syndrome Details Oliceridine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Oliceridine Enasidenib Idhifa Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Encorafenib Braftovi Reduced oliceridine exposure and reduced efficacy of oliceridine Details Oliceridine Esketamine Nasal Spray Spravato An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Oliceridine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details Oliceridine Furosemide Injection Disal Reduced efficacy of diuretics Details Oliceridine Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oliceridine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Oliceridine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Oliceridine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details Oliceridine Hydromorphone Rectal available generically Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.