Dasabuvir and Dolutegravir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dolutegravir
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dasabuvir and dolutegravir plasma concentrations
Interaction Deep Dive
Concomitant use of dasabuvir (a P-gp substrate and BCRP inhibitor) and dolutegravir (a P-gp inhibitor and BCRP substrate) may result in increased plasma concentrations of both drugs1. Use caution if coadministered and monitor for increased adverse events associated with both agents.
Why it happens (mechanism)
Inhibition of P-gp efflux transport of dasabuvir; inhibition of BCRP efflux transport of dolutegravir
Common questions
Can I take Dasabuvir and Dolutegravir together?
Increased dasabuvir and dolutegravir plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dasabuvir and Dolutegravir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dasabuvir or Dolutegravir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
Keep reading about Dolutegravir
Keep reading about Dasabuvir
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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