Digoxin and Aminosalicylic Acid: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Digoxin
Aminosalicylic Acid
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced digoxin serum concentrations
Interaction Deep Dive
In two of ten patients, digoxin levels were reduced by 40% eight hours after the last dose of aminosalicylic acid 2 grams four times daily1. Aminosalicylic acid may decrease the absorption of digoxin. Aminosalicylic acid is believed to inhibit the function of intestinal absorbing cells. Thus, separation of the doses of these agents would not prevent the interaction. Patients receiving both agents should be monitored for reduced digoxin response.
Why it happens (mechanism)
Inhibition of digoxin intestinal absorption
Common questions
Can I take Digoxin and Aminosalicylic Acid together?
Reduced digoxin serum concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Aminosalicylic Acid interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Digoxin or Aminosalicylic Acid need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Paser(TM), aminosalicylic acid. Jacobus Pharmaceutical Co. Inc. Princeton, NJ, 1996.
Keep reading about Digoxin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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