Digoxin and Exenatide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Exenatide
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced digoxin exposure
Interaction Deep Dive
Concomitant use of digoxin and exenatide may reduce digoxin exposure. The patient should wait at least 1 hour after taking digoxin before using exenatide3. Measure digoxin exposure before initiating exenatide. Increase the digoxin dose by approximately 20% to 40%, if necessary, and continue monitoring digoxin exposure 12.
Why it happens (mechanism)
Slowed gastric emptying by exenatide
Literature reports
1 report — tap to read
a) The administration of multiple doses of exenatide 10 mcg twice daily 30 minutes before oral digoxin 0.25 mg once daily decreased the digoxin Cmax by 17% and delayed the Tmax by approximately 2.5 hours; however, the digoxin AUC was unchanged 3.
Common questions
Can I take Digoxin and Exenatide together?
Reduced digoxin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Exenatide interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Digoxin or Exenatide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: LANOXIN(R) oral tablets, digoxin oral tablets. Concordia Pharmaceuticals Inc (per FDA), Kansas City, MO, 2019. DailyMed
- Product Information: DIGOXIN oral tablets, digoxin oral tablets. Aurobindo Pharma USA, Inc. (per Dailymed), East Windsor, NJ, May. DailyMed
- Product Information: BYETTA(R) subcutaneous injection, exenatide subcutaneous injection. Amylin Pharmaceuticals, Inc. and Eli Lilly and Company (per manufacturer), San Diego, CA, 2011. DailyMed
Keep reading about Exenatide
Keep reading about Digoxin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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