Digoxin and Magnesium Sulfate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Digoxin
Magnesium Sulfate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced absorption of digoxin
Interaction Deep Dive
Administer digoxin at least 2 hours before and not less than 6 hours after administration of sodium sulfate/potassium sulfate/magnesium sulfate to avoid chelation with magnesium1.
Why it happens (mechanism)
Chelation with magnesium
Common questions
Can I take Digoxin and Magnesium Sulfate together?
Reduced absorption of digoxin Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Magnesium Sulfate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Digoxin or Magnesium Sulfate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: SUPREP(R) Bowel Prep Kit oral solution, sodium sulfate, potassium sulfate, magnesium sulfate oral solution. Braintree Laboratories Inc (per FDA), Braintree, MA, 2020. DailyMed
Keep reading about Digoxin
Keep reading about Magnesium Sulfate
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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