Digoxin

453 interactions 2 explained in plain English 980 cited references

Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®

About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Maribavir Cyclosporine Ophthalmic Parathyroid Hormone Injection Mavorixafor Mefenamic Acid

1 Contraindicated 359 Major 91 Moderate 2 Minor

All (453) Contraindicated (1) Major (359) Moderate (91) Minor (2)

Moderate

Digoxin Trospium / Xanomeline Cobenfy Explained Increased oral P-gp substrate with NTI exposure and an increased risk on severity and frequency of oral P-gp substrate with NTI-re... Details Digoxin Atenolol Tenormin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Acebutolol Sectral® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Amphotericin B Injection Abelcet Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details Digoxin Betaxolol Betoptic S Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Betaxolol Ophthalmic Betoptic® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Bisoprolol Zebeta® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Chloroquine Aralen® Increased serum digoxin concentration Details Digoxin Cyclophosphamide Cytoxan® Decreased digoxin effectiveness Details Digoxin Cyclophosphamide Injection Cytoxan® Injection Decreased digoxin effectiveness Details Digoxin Dexlansoprazole Dexilant An increased risk of digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Diazepam Nasal Spray Valtoco Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Diazepam Rectal Diastat Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Aloe Hypokalemia resulting in digoxin toxicity Details Digoxin Amiloride Decreased digoxin effectiveness Details Digoxin Aminosalicylic Acid Reduced digoxin serum concentrations Details Digoxin Amphotericin B Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details Digoxin Amphotericin B Cholesteryl Sulfate Complex Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details Digoxin Amphotericin B Lipid Complex Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details Digoxin Amphotericin B Liposome Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details Digoxin Arbutamine Unreliable arbutamine test results Details Digoxin Arotinolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Atazanavir Reyataz Increased digoxin exposure Details Digoxin Azosemide Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Befunolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Bevantolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Bopindolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Brimonidine Alphagan An increased risk of reduced blood pressure Details Digoxin Bucindolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Bumetanide Bumex Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Bupranolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Carob Increased digoxin toxicity Details Digoxin Carteolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Cascara Sagrada Hypokalemia secondary to cascara sagrada bark intake, which may increase the risk of digoxin toxicity Details Digoxin Celiprolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Dalfopristin Increased digoxin levels and digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Diazepam Diastat Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Dilevalol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Disopyramide Norpace Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Esmolol Brevibloc Increased risk of bradycardia and possible digitalis glycoside toxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.