Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Cyclopenthiazide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Cyclosporine Atopica Increased digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Cyclothiazide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Daclatasvir Daklinza® Increased digoxin exposure Details Digoxin Danicopan Voydeya Increased P-gp substrate exposure Details Digoxin Daridorexant Increased digoxin exposure Details Digoxin Darunavir Increased digoxin exposure Details Digoxin Deutivacaftor Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Digoxin Dexibuprofen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Dexketoprofen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Dicloxacillin Reduced digoxin exposure Details Digoxin Difenoxin Increased digoxin exposure Details Digoxin Diflunisal Dolobid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Dihydroxyaluminum Aminoacetate Reduced digoxin exposure Details Digoxin Dihydroxyaluminum Sodium Carbonate Reduced digoxin exposure Details Digoxin Diltiazem Cardizem Increased digoxin exposure and an increased risk of bradycardia and advanced complete heart block Details Digoxin Diosmin Increased digoxin exposure Details Digoxin Diphenoxylate Increased digoxin exposure Details Digoxin Dipyrone Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Dofetilide Tikosyn An increased risk of cardiotoxicity (torsade de pointes) Details Digoxin Dopamine An increased risk of cardiotoxicity (arrhythmias) Details Digoxin Doxercalciferol Hectoral® Increased risk of digoxin toxicity Details Digoxin Dronedarone Multaq Increased digoxin exposure and increased conduction effects of dronedarone Details Digoxin Droxicam Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Efavirenz Reduced digoxin exposure Details Digoxin Elacestrant Orserdu Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Digoxin Elagolix Orilissa Increased digoxin exposure Details Digoxin Eliglustat Cerdelga Increased digoxin exposure Details Digoxin Enalapril Epaned An increased digoxin exposure Details Digoxin Enalaprilat An increased digoxin exposure Details Digoxin Ensitrelvir Increased risk of P-gp substrate exposure Details Digoxin Entrectinib Rozlytrek Increased digoxin exposure Details Digoxin Enzalutamide Xtandi Increased digoxin exposure Details Digoxin Ephedrine Increased risk of arrhythmias Details Digoxin Epinephrine An increased risk of cardiotoxicity (arrhythmias) Details Digoxin Epoprostenol Flolan Increased digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Eprosartan Teveten® An increased digoxin exposure Details Digoxin Erdafitinib Balversa Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Digoxin Erythromycin Erythrocin Stearate Increased digoxin exposure and digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Esomeprazole Nexium Increased digoxin exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.