Digoxin and Darunavir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Darunavir
No brand names on recordDigoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased digoxin exposure
Interaction Deep Dive
Digoxin AUC and Cmax increased when coadministered with darunavir/ritonavir. If these agents are coadministered, digoxin treatment should be initiated at the lowest dose. Digoxin serum concentrations should be monitored closely and the digoxin dose titrated accordingly1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) Concurrent administration of digoxin and darunavir/ritonavir led to increases in digoxin AUC (least-square mean ratio 1.36, 90% confidence interval (CI), 0.81 to 2.27) and Cmax (least-square mean ratio 1.15, 90% CI, 0.89 to 1.48). Oral darunavir 600 mg/ritonavir 100 mg twice daily were coadministered with oral digoxin 0.4 mg in 8 subjects1.
Common questions
Can I take Digoxin and Darunavir together?
Increased digoxin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Darunavir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Digoxin or Darunavir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: PREZISTA(R) oral suspension, oral tablets, darunavir oral suspension, oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2023. DailyMed
Keep reading about Darunavir
Keep reading about Digoxin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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