Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Ivacaftor Kalydeco Increased digoxin exposure Details Digoxin Kaolin Pet Pectillin Reduced digoxin exposure Details Digoxin Ketoconazole Extina Increased digoxin exposure Details Digoxin Ketoprofen Actron® Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Ketorolac Acular Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Kyushin Increased risk of digoxin toxicity Details Digoxin Lansoprazole Prevacid An increased digoxin exposure Details Digoxin Lapatinib Tykerb Increased exposure of digoxin Details Digoxin Lasmiditan Reyvow Increased exposure of P-gp substrate and risk of toxicity Details Digoxin Ledipasvir Increased digoxin exposure Details Digoxin Lenacapavir Sunlenca Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Lercanidipine An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Levothyroxine Ermeza Reduced digoxin exposure Details Digoxin Lily Of The Valley Increased risk of digoxin toxicity Details Digoxin Liothyronine Cytomel Reduced digoxin exposure Details Digoxin Lonafarnib Zokinvy Increased digoxin exposure and an increased risk of digoxin-related adverse effects Details Digoxin Lorlatinib Lorbrena Reduced digoxin exposure and reduced efficacy of digoxin Details Digoxin Lornoxicam Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Losartan Arbli An increased digoxin exposure Details Digoxin Loxoprofen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Lumacaftor Increased or decreased digoxin exposure Details Digoxin Lumiracoxib Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Magaldrate Reduced digoxin exposure Details Digoxin Magnesium Carbonate Reduced digoxin exposure Details Digoxin Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Reduced digoxin exposure Details Digoxin Magnesium Oxide Mag-Ox 400 Reduced digoxin exposure Details Digoxin Magnesium Peroxide Reduced digoxin exposure Details Digoxin Magnesium Sulfate Reduced absorption of digoxin Details Digoxin Magnesium Trisilicate Reduced digoxin exposure Details Digoxin Manidipine An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Maribavir Livtencity Increased digoxin exposure and an increased risk of digoxin-related adverse events Details Digoxin Mavorixafor Xolremdi Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Meclofenamate Meclodium® Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Mefenamic Acid Ponstel® Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Meloxicam Alloxate Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Metformin Fortamet® Increased digoxin exposure Details Digoxin Methyclothiazide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Metoclopramide Reduced digoxin exposure Details Digoxin Metolazone Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Mibefradil Increased digoxin exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.