Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Trofinetide Daybue Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Tucatinib Tukysa Increased exposure to P-gp substrate and risk of toxicity Details Digoxin Valbenazine Ingrezza Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Valdecoxib Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Valsartan Diovan An increased digoxin exposure Details Digoxin Vandetanib Caprelsa Increased digoxin exposure Details Digoxin Velpatasvir Increased digoxin exposure Details Digoxin Vemurafenib Zelboraf Increased digoxin exposure Details Digoxin Venetoclax Venclexta Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Digoxin Vepdegestrant Veppanu Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Digoxin Verapamil Calan Increased digoxin exposure, increased risk of digitalis toxicity and an increased risk of complete heart block Details Digoxin Vibegron Gemtesa Increased digoxin exposure Details Digoxin Vilazodone Viibryd Increased P-gp substrate exposure Details Digoxin Vimseltinib Romvimza Increased risk of P-gp substrate exposure Details Digoxin Voclosporin Lupkynis Increased digoxin exposure Details Digoxin Vonoprazan Voquezna An increased risk of digoxin toxicity Details Digoxin Vorapaxar Zontivity Increased digoxin exposure Details Digoxin Voxilaprevir Increased digoxin exposure Details Digoxin Xipamide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Zanubrutinib Brukinsa Increased digoxin exposure Details Digoxin Doxercalciferol Injection Hectorol Increased risk of digoxin toxicity Details Digoxin Esomeprazole Injection Nexium Increased digoxin exposure Details Digoxin Exenatide Injection Bydureon Reduced digoxin exposure Details Digoxin Flurbiprofen Ophthalmic Ocufen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Gentamicin Injection Garamycin® I.V. Increased digoxin exposure Details Digoxin Gentamicin Ophthalmic Garamycin® Ophthalmic Increased digoxin exposure Details Digoxin Gentamicin Topical Garamycin® Increased digoxin exposure Details Digoxin Ketoconazole Topical Extina® Foam Increased digoxin exposure Details Digoxin Ketorolac Injection Acular Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Ketorolac Nasal Spray Sprix Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Ketorolac Ophthalmic Acular Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Lenacapavir Injection Sunlenca Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Lenacapavir Oral Sunlenca Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Meloxicam Injection Alloxate Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Metoclopramide Injection Gimoti Reduced digoxin exposure Details Digoxin Metoclopramide Nasal Spray Gimoti Reduced digoxin exposure Details Digoxin Minocycline Topical Amzeeq Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Octreotide Injection Bynfezia Decreased digoxin exposure Details Digoxin Parathyroid Hormone Injection Natpara Increased risk of digoxin toxicity and reduced digoxin exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.