Doxylamine

24 interactions 2 explained in plain English
Also sold as: Aldex AN Nocto Unisom Wal-Som (doxylamine) Zzzquil Ultra
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Acetaminophen And Codeine Buprenorphine Hydromorphone Rectal Diphenhydramine Injection Fentanyl Transdermal Patch
1 Contraindicated 22 Major 1 Moderate
All (24) Contraindicated (1) Major (22) Moderate (1)

Contraindicated

Doxylamine Linezolid Injection Zyvox Prolonged and intensified anticholinergic effects (eg, severe dry mouth, constipation, decreased urination or sweating) Details

Major

Doxylamine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Doxylamine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Doxylamine Aripiprazole Injection Abilify Increased risk of CNS depression Details Doxylamine Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Doxylamine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Doxylamine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Doxylamine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Doxylamine Diazepam Rectal Diastat Increased risk of CNS depression Details Doxylamine Diphenhydramine Injection Banophen Increased risk of CNS depression Details Doxylamine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Doxylamine Esketamine Nasal Spray Spravato Increased risk of sedation Details Doxylamine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Doxylamine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Doxylamine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Doxylamine Hydroxychloroquine Plaquenil An increased risk of seizures Details Doxylamine Lacosamide Injection Motpoly An increased risk of CNS depression Details Doxylamine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Doxylamine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Doxylamine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Doxylamine Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details Doxylamine Midazolam Injection Nayzilam Increased risk of CNS depression Details Doxylamine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details

Moderate

Doxylamine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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