Entacapone

57 interactions 119 cited references

Also sold as: Comtan Comtan®

About Entacapone

Entacapone is a COMT inhibitor used with other Parkinson's medications to reduce end-of-dose symptom worsening. Read the full Entacapone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Furazolidone Nialamide Methylene Blue Linezolid Isocarboxazid Iproniazid

11 Contraindicated 26 Major 20 Moderate

All (57) Contraindicated (11) Major (26) Moderate (20)

Contraindicated

Entacapone Furazolidone Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Iproniazid Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Isocarboxazid Marplan Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Linezolid Zyvox Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Methylene Blue Provayblue Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Nialamide Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Pargyline Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Phenelzine Nardil Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Procarbazine Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Tranylcypromine Parnate Decreased catecholamine metabolism and risk for hypertensive crisis Details Entacapone Linezolid Injection Zyvox Decreased catecholamine metabolism and risk for hypertensive crisis Details

Major

Entacapone Dobutamine An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Dopamine An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Apomorphine Apokyn An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Bitolterol An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Desipramine Norpramin An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Epinephrine An increased risk of tachycardia, hypertension and arrhythmias Details Entacapone Fluvastatin Lescol Increased exposure of CYP2C9 substrate Details Entacapone Glimepiride Amaryl Increased glimepiride exposure Details Entacapone Glipizide Glucotrol Increased exposure of CYP2C9 substrate Details Entacapone Glyburide DiaBeta® Increased exposure of CYP2C9 substrate Details Entacapone Irbesartan Avapro Increased exposure of CYP2C9 substrate Details Entacapone Isoetharine An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Isoproterenol An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Losartan Arbli Increased exposure of CYP2C9 substrate Details Entacapone Methyldopa Aldomet® An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Metoclopramide Diminished effectiveness of metoclopramide and the dopaminergic agent Details Entacapone Nateglinide Starlix® Increased exposure of CYP2C9 substrate Details Entacapone Norepinephrine An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Rosiglitazone Avandia® Increased exposure of CYP2C9 substrate Details Entacapone Tolbutamide Orinase® Increased exposure of CYP2C9 substrate Details Entacapone Venlafaxine An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Voriconazole Vfend Increased exposure of CYP2C9 substrate Details Entacapone Warfarin Coumadin Increased warfarin exposure and increased risk for bleeding Details Entacapone Isoetharine Oral Inhalation Beta-2® An increased risk of tachycardia, hypertension, and arrhythmias Details Entacapone Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Entacapone Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details

Moderate

Entacapone Ampicillin Amcill® An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Entacapone Ampicillin Injection Omnipen-N® An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Entacapone Chloramphenicol Injection Chloromycetin® Injection An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.