Drug & supplement interaction

Cabbage + Entacapone

Entacapone brand name: Comtan.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cabbage has a moderate interaction with Entacapone. Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cabbage and Entacapone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

GLUCURONIDATED DRUGS

Why this applies to Entacapone

Entacapone falls under GLUCURONIDATED DRUGS — the group Cabbage interacts with.

Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for entacapone (Comtan). Your body clears this drug partly through a process called glucuronidation, basically a tagging system the liver uses to package drugs for removal. Cabbage (and its cousin, Brussels sprouts) may rev that process up a bit. In a small study, eating these veggies daily lowered blood levels of some drugs cleared this way.

So in theory, regularly eating large amounts could leave a little less entacapone around, which means it might not extend your levodopa's effect quite as well. That could show up as more of those wearing-off Parkinson's symptoms returning between doses. This is still pretty theoretical, and normal dinner-sized portions are unlikely to cause trouble. If you eat a lot of cabbage daily or use concentrated supplements, just mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cabbage Also Interacts With Other Medications

Cabbage has 324 moderate known drug interactions in our database — the Entacapone one above is one of them. If you take anything else, check it against the full list below.

Moderate 324 No known interaction 2,506 (incl. Entacapone)
Taking anything else?

Check Another of Your Medications Against Cabbage

Covers the 2,830 medications we’ve checked against Cabbage. Pick one to open its full report.

From our Q&A

Questions About Cabbage or Entacapone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cabbage or Entacapone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Entacapone

This page covers Cabbage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entacapone page lists 33 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ayahuasca (moderate), Black Horehound (moderate), Breadfruit (moderate) and Brussels Sprout (moderate).

By severity: 1 major · 22 moderate · 10 minor.

Open the Entacapone interaction page

One more smart check

Taking Cabbage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,304 real supplement products containing Cabbage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cabbage. Your product may carry other ingredients that interact with Entacapone too, on top of Cabbage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cabbage and Entacapone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cabbage
Top 25%

#185 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Entacapone
Top 25%

#694 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cabbage

What is Cabbage?

Cabbage
  • Breast engorgement during breastfeeding
  • Joint pain and swelling (topical)
  • Digestive and stomach upset
  • General nutrition and antioxidant support
  • Skin and minor inflammation (topical)

Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims are based on tradition or limited research, with the strongest (though still modest) evidence being for cooling cabbage leaves on engorged breasts. Talk to your pharmacist or doctor before using cabbage in large amounts or as a treatment.

Read the full Cabbage monograph & all interactions
Medication

About Entacapone

What Is Entacapone Used For?

Brand name: Comtan

Entacapone tablets are used as an add-on therapy — always taken together with levodopa and carbidopa — to treat end-of-dose 'wearing-off' in people with Parkinson's disease. 'Wearing-off' is when the benefit of a levodopa dose fades before the next dose is due, causing symptoms like stiffness or slowness to return.

Entacapone has no effect on Parkinson's disease on its own; it only works when combined with levodopa and carbidopa. Its effectiveness has not been thoroughly studied in people with Parkinson's disease who do not experience wearing-off.

See full Entacapone drug information
Keep checking

Other Drugs & Cabbage

Browse every other medication we’ve checked against Cabbage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
324Moderate
0Minor
2,505No known interaction
324 Moderate 2,505 No interaction
Moderate

324 interactions

Showing 60 of 324 moderate interactions — see all 324 on the Cabbage page.

No interaction 2,505 drugs checked — show the list

We also checked Cabbage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,505 medications checked with no known interaction — see the full Cabbage list.

See the full Cabbage interactions page
See every supplement checked against Entacapone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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Pharmacist Counseling Corner

Taking Cabbage and Entacapone Together: Common Questions

Can you take Cabbage with Entacapone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cabbage and Entacapone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Entacapone and Cabbage?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.