Epinephrine

31 interactions 2 explained in plain English

Read the full Epinephrine drug information page

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Epinephrine Amitriptyline Elavil Explained Increased epinephrine effects and an increased risk of hypertension Details Epinephrine Atenolol Tenormin Explained An increased risk of cardiac arrhythmias, an antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increas... Details Epinephrine Acebutolol Sectral® An increased risk of cardiac arrhythmias, an antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increas... Details Epinephrine Atropine Ophthalmic Atropine Care 1% An increased risk of cardiac arrhythmias Details Epinephrine Betaxolol Betoptic S Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Epinephrine Betaxolol Ophthalmic Betoptic® Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Epinephrine Bisoprolol Zebeta® Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Epinephrine Digoxin Cardoxin® An increased risk of cardiotoxicity (arrhythmias) Details Epinephrine Diphenhydramine Injection Banophen Increased EPINEPHrine effects Details Epinephrine Diphenhydramine Topical Afterbite with Antihistamine Increased EPINEPHrine effects Details Epinephrine Disopyramide Norpace An increased risk of cardiac arrhythmias Details Epinephrine Dofetilide Tikosyn An increased risk of cardiac arrhythmias Details Epinephrine Entacapone Comtan An increased risk of tachycardia, hypertension and arrhythmias Details Epinephrine Esmolol Brevibloc An increased risk of cardiac arrhythmias, an antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increas... Details Epinephrine Fexofenadine Allegra Reduced or reversal of EPINEPHrine pressor response Details Epinephrine Flecainide Tambocor® An increased risk of cardiac arrhythmias Details Epinephrine Furosemide Injection Disal An increased risk of cardiac arrhythmias Details Epinephrine Labetalol Normodyne® Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Epinephrine Levobunolol Ophthalmic AKBeta® Antagonized cardio stimulating, bronchodilation effects of EPINEPHrine, increased risk of hypertension, increased risk of bradycar... Details Epinephrine Levothyroxine Ermeza Increased EPINEPHrine effects Details Epinephrine Methylergonovine Methergine Reversed pressor effects of EPINEPHrine, an increased risk of hypertension or an increased risk of cerebrovascular accidents Details Epinephrine Mexiletine Mexitil® An increased risk of cardiac arrhythmias Details Epinephrine Nadolol Corgard Antagonized cardio stimulating, bronchodilation effects of EPINEPHrine, increased risk of hypertension, increased risk of bradycar... Details Epinephrine Nebivolol Bystolic Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Epinephrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Epinephrine Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Epinephrine Penbutolol Levatol® Antagonized cardio stimulating, bronchodilation effects of EPINEPHrine and an increased risk of hypertension Details

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