FDA-filed SPL labeling · retrieved through openFDA

Epinephrine

Epinephrine is a fast-acting emergency medicine used to treat severe allergic reactions (anaphylaxis) and, in certain injectable forms, low blood pressure from septic shock.

Brand names Auvi-QAdrenalinSymjepiPrimatene Mist Inhalerneffy +11 more
Drug classes ⓘ Alpha-adrenergic Agonist
Rx/OTC Forms 6 Routes Intramuscular, Intravenous, Subcutaneous · Intramuscular · Subcutaneous · Intravenous +11
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 88 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveFeb 15, 2023
Clinical labels in scope ⓘ88
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ1948
FDA-listed product records ⓘ275
Boxed warningNone found in compared labels
How we combine label and product data →
Other forms & routes:
Injection Oral inhalation
⭐ Epinephrine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Epinephrine is the first-line emergency treatment for life-threatening allergic reactions (anaphylaxis) — it works fast to open airways, raise blood pressure, and reduce dangerous swelling. Always carry your prescribed form and use it at the first signs of a severe allergic reaction, then call 911 and get to an emergency room immediately. It is a bridge to emergency care, not a replacement for it.
How we write & review this content — our editorial policy →

📖 Epinephrine: Patient Information Guide

A plain-language walkthrough of Epinephrine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Epinephrine is used across several products and delivery forms to treat life-threatening allergic emergencies and, in specific injectable preparations, low blood pressure from septic shock.

  • Emergency treatment of anaphylaxis (severe allergic reactions) triggered by insect stings or bites, foods, drugs, diagnostic substances, allergen immunotherapy, or unknown/exercise-related causes — supported across epinephrine auto-injectors, Adrenalin injection, and Neffy nasal spray
  • Neffy nasal spray is approved specifically for adults and children 4 years and older who weigh at least 15 kg
  • Adrenalin injection (intramuscular, subcutaneous, or intravenous) is indicated to raise blood pressure in adult patients with low blood pressure caused by septic shock
  • Adrenalin (epinephrine in sodium chloride) intravenous infusion is indicated for low blood pressure from septic shock in adults
  • Primatene Mist inhaler is used for temporary relief of mild intermittent asthma symptoms — wheezing, chest tightness, and shortness of breath
⚙️How it works▾

Epinephrine activates two families of receptors throughout the body — alpha and beta adrenergic receptors. Stimulating alpha receptors constricts (tightens) blood vessels, reversing the dangerous blood pressure drop and fluid leakage that occur during anaphylaxis. Stimulating beta receptors relaxes the muscles around the airways, rapidly opening them to relieve wheezing and breathlessness. Together, these actions also reduce hives, itching, swelling (including angioedema — swelling under the skin), and gastrointestinal symptoms tied to the allergic reaction.

💊How it's taken▾

The right form and amount of epinephrine depend on the situation, the patient's weight, and the specific product prescribed. Auto-injectors and vial-based injections go into the outer thigh (intramuscularly or subcutaneously); Neffy goes into a nostril; Primatene Mist is inhaled; and intravenous Adrenalin is given only in clinical settings. Injections may be repeated every 5–10 minutes if needed, but more than two doses should only be given under direct medical supervision.

  • Always follow your prescriber's instructions and the directions printed on your specific device or package
  • After using any epinephrine product for anaphylaxis, go to an emergency room immediately — even if you feel better
  • Keep two doses available at all times if prescribed a portable product
🤒Side effects — in detail▾

Common side effects of epinephrine reflect its powerful action on the heart and nervous system, and — for nasal spray — local irritation in the nose.

  • Nasal discomfort, runny nose, sneezing, or nasal congestion (Neffy)
  • Headache
  • Feeling jittery or anxious
  • Rapid heartbeat (tachycardia)
  • Nausea or vomiting
  • Dizziness
  • Throat irritation
  • Sweating, paleness, or tremor

More serious reactions — including dangerous heart rhythm problems (arrhythmias), very high blood pressure, cerebral hemorrhage (bleeding in the brain), and serious skin infections at the injection site — have been reported. Seek emergency care if you experience chest pain, irregular heartbeat, severe headache, or any signs of infection at an injection site.

⚠️Warnings & precautions▾
  • Always go to the ER after use: Epinephrine is emergency supportive therapy — it is not a substitute for hospital care. Call 911 or have someone take you to the nearest emergency room after every use.
  • Inject only into the outer thigh: Never inject into the buttocks (risk of serious bacterial infection including gas gangrene), and never into fingers, hands, or feet (risk of dangerously reduced blood flow to those areas).
  • Serious skin infections: Rare but life-threatening infections (including necrotizing fasciitis — rapidly spreading tissue infection) have occurred at injection sites. Watch for persistent redness, warmth, swelling, or tenderness and seek care promptly.
  • Heart disease: Epinephrine should be used with caution in people with heart disease, arrhythmias, coronary artery disease, or high blood pressure — but it must never be withheld in a true life-threatening emergency.
  • Children: Hold a young child's leg firmly before and during injection to prevent injury from kicking or movement.
  • Sulfite sensitivity: Some epinephrine products contain sodium metabisulfite. This should not prevent use in a life-threatening situation — the risk of untreated anaphylaxis is far greater.
🔀What it interacts with▾

Several medications can make epinephrine stronger, weaker, or more likely to cause heart problems — always tell your doctor and pharmacist everything you take.

  • Tricyclic antidepressants and MAO inhibitors: Can strongly amplify epinephrine's effects, raising the risk of dangerously high blood pressure and heart problems
  • Cardiac glycosides, diuretics, anti-arrhythmics: Increase the risk of abnormal heart rhythms when used alongside epinephrine
  • Beta-blockers (e.g., propranolol): Can blunt epinephrine's ability to open airways and stimulate the heart — potentially reducing its effectiveness
  • Alpha-blockers (e.g., phentolamine): Can block epinephrine's blood-pressure-raising effects
  • Levothyroxine and certain antihistamines (e.g., diphenhydramine, chlorpheniramine): May intensify epinephrine's effects
  • COMT inhibitors (e.g., entacapone): Can potentiate (strengthen) epinephrine's actions
  • Ergot alkaloids: May reverse epinephrine's blood pressure effects
  • Neffy and other nasal products: Neffy may change the nasal lining for up to 2 weeks after use, potentially increasing absorption of other nasal spray medications

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have heart disease, coronary artery disease, irregular heart rhythm, or high blood pressure
  • Tell your doctor if you have hyperthyroidism (overactive thyroid), diabetes, or Parkinson's disease
  • Older adults are more sensitive to epinephrine and at higher risk for serious side effects — use with caution
  • Pregnant women: do not delay treatment for anaphylaxis — untreated anaphylaxis is dangerous for both mother and baby; decades of evidence have not shown a clear drug-related risk of birth defects at therapeutic doses
  • Breastfeeding: epinephrine transfers into breast milk in very low amounts; do not delay emergency treatment
  • Neffy is not approved for children under 4 years old or those weighing less than 15 kg
  • There are no absolute contraindications to epinephrine in a life-threatening allergic emergency — its benefits outweigh the risks in anaphylaxis regardless of underlying conditions
🚑If you take too much▾

Too much epinephrine can cause extremely high blood pressure, which may lead to bleeding in the brain (cerebrovascular hemorrhage) — particularly in older adults. Overdose can also cause a buildup of fluid in the lungs, dangerous heart rhythm problems (including fatal ventricular fibrillation), very pale and cold skin, and kidney failure.

If you suspect an overdose, call Poison Control at 1-800-222-1222 or seek emergency medical care immediately. Treatment is primarily supportive and focuses on managing blood pressure and heart rhythm.

📡Pharmacodynamics — effects in the body▾

Epinephrine raises both systolic blood pressure and pulse rate, which helps reverse the cardiovascular collapse of anaphylaxis. Studies of Neffy nasal spray showed that blood pressure and heart rate responses after one nasal dose were generally within the range seen after intramuscular epinephrine injection during the first 10 minutes. Nasal congestion (such as from allergic rhinitis) may affect how quickly Neffy is absorbed, and the full clinical meaning of blood pressure and pulse changes observed in healthy volunteers may differ from responses in someone actively experiencing anaphylaxis.

🔬Pharmacokinetics — how your body processes it▾

After a single nasal dose of Neffy, plasma epinephrine concentrations over 60 minutes were generally within the range seen after an intramuscular injection. Neffy's peak concentration (Cmax) was reached at a median of about 30 minutes in healthy adults — somewhat later than with an auto-injector but in a clinically similar range. Nasal congestion from allergic rhinitis can initially speed absorption but may reduce overall exposure after about 20 minutes. Epinephrine is rapidly broken down by the body, which is why its effects are short-lived and repeat dosing may be needed.

📦How to store it▾

Protect from light. Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Do not refrigerate.

📄 Written from Epinephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Epinephrine — the kind of thing our pharmacy team would talk through with you at the counter.

Why do I need to go to the ER after using my EpiPen or Auvi-Q if I already feel better? ▾
Epinephrine works fast but wears off quickly — sometimes in as little as 15 to 20 minutes. Anaphylaxis can come back (this is called a biphasic reaction), and you may need additional treatment or monitoring that only a hospital can provide. Think of the injection as buying you time, not solving the problem. Always call 911 or have someone drive you to the ER after every use, even if you feel completely fine.
Where exactly do I inject it, and does it matter? ▾
Yes, it absolutely matters. Inject into the outer thigh — you can even go through your clothing if needed. Never inject into the buttocks (that spot carries a risk of serious infection), and never accidentally inject into a finger, hand, or foot, which could cut off blood flow to that area. If an accidental injection happens somewhere other than the thigh, go to the emergency room right away and tell them where it went in.
How does Neffy (the nasal spray) work differently from an injection? ▾
Neffy delivers epinephrine through the lining of your nostril instead of through a needle. Studies show that blood levels of epinephrine after one dose of Neffy are generally in a similar range to those after an intramuscular injection. One thing to keep in mind: if your nose is very congested — say from a cold or bad allergies — absorption may be a bit different. If symptoms don't improve within 5 minutes, a second spray in the same nostril is recommended. Either way, you still need to get to the ER after using it.
I take a beta-blocker for my heart. Will epinephrine still work for me? ▾
Beta-blockers can reduce some of epinephrine's effects — particularly its ability to open your airways and stimulate your heart. That said, epinephrine is still the right treatment for anaphylaxis and should never be skipped. Let your doctor know you take a beta-blocker so they can plan ahead, and make sure your emergency action plan accounts for this. In a true emergency, always use your epinephrine first.
Is it safe to use epinephrine if I'm pregnant? ▾
Yes — and it's very important that you do if you're having anaphylaxis. Untreated anaphylaxis during pregnancy is far more dangerous to both you and your baby than the medication itself. Decades of real-world experience have not shown a clear risk of birth defects at the doses used in emergencies. Don't hesitate to use it if you need it, and get emergency care right away.
What side effects should I expect after using epinephrine, and which ones mean I should call for help? ▾
After using epinephrine, it's totally normal to feel your heart racing, feel jittery or anxious, feel shaky, or get a headache — these are direct effects of the medication doing its job. With Neffy, you might notice nasal discomfort or a runny nose. What you should watch for and report right away: chest pain, very fast or irregular heartbeat, severe headache, signs of infection at the injection site (redness, warmth, swelling that doesn't go away), or any symptoms of the allergic reaction coming back. Always be evaluated at an ER after use.
Is Epinephrine available over the counter? ▾
Both — Epinephrine is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Epinephrine first available? ▾
Epinephrine has been available in the United States since at least 1948, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Epinephrine? ▾
Epinephrine is supplied by 68 manufacturers listed in the FDA NDC Directory, including HF Acquisition Co LLC, DBA HealthFirst, Medical Purchasing Solutions, LLC, Remedyrepack Inc..

💬 Answers drafted from Epinephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

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💊 How Epinephrine comes

Epinephrine is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

By injection · Endotracheal · In the eye · Into a muscle · Into a vein · Intracardiac · Under the skin
Brands Adrenalin Auvi-Q Epinephrine 0.3 Adults Epinephrine Pediatrics Epipen Epipen Jr Symjepi
How this form is used
What it may be used for
  • Epinephrine injection auto-injectors (including Auvi-Q, EpiPen, and epinephrine USP auto-injectors) are used for emergency treatment of anaphylaxis in people at increased risk of severe allergic reactions
  • Adrenalin injection is used for emergency treatment of anaphylaxis and to raise blood pressure in adult patients with low blood pressure from septic shock
  • Adrenalin (epinephrine in sodium chloride) intravenous infusion is indicated to raise blood pressure in adults with septic shock
  • Auvi-Q is available in three dose strengths selected by body weight for emergency anaphylaxis treatment
Important instructions
  • Auto-injectors (Auvi-Q, EpiPen, and epinephrine USP auto-injectors) should be injected into the outer thigh — through clothing if needed — never into the buttocks, fingers, hands, or feet
  • Adrenalin vial injection should be given into the anterolateral (outer) thigh; the injection may be repeated every 5 to 10 minutes if needed — do not inject repeatedly at the same spot
  • Adrenalin (epinephrine in sodium chloride) for intravenous use requires no further dilution and must be infused into a large vein; weaning gradually is recommended
  • After any injection, go to the nearest emergency room immediately for further monitoring and care
Available strengths 14 strengths
8 mcg/mL 16 mcg/mL 20 mcg/mL 32 mcg/mL 40 mcg/mL 64 mcg/mL
Show 8 more strengths Show fewer strengths
0.1 mg/0.1 mL 0.1 mg/mL 0.15 mg/0.3 mL 0.15 mg/0.15 mL 0.3 mg/0.3 mL 0.5 mg/mL 1 mg/mL 30 mg/30 mL
220 FDA-listed product records ⓘ

Nasal spray

In the nose
Brands Neffy
How this form is used
What it may be used for
  • Neffy is approved for emergency treatment of Type I allergic reactions, including anaphylaxis, in adults and children 4 years and older who weigh at least 15 kg (about 33 lbs)
  • Neffy provides a needle-free option for epinephrine delivery during an anaphylactic emergency
Important instructions
  • Neffy is sprayed into one nostril; dose is based on the patient's body weight
  • If symptoms do not improve or worsen after the first dose, a second spray into the same nostril can be given at least 5 minutes later using a new nasal spray
  • It is recommended to have two Neffy nasal sprays available at all times
  • After using Neffy, seek emergency medical care immediately
Available strengths 2 strengths
EPINEPHRINE 1 mg/100uL EPINEPHRINE 2 mg/100uL
5 FDA-listed product records ⓘ

Inhaler

Inhaled
Brands Primatene Mist
How this form is used
What it may be used for
  • Primatene Mist is used for temporary relief of mild symptoms of intermittent asthma
  • Primatene Mist relieves wheezing, chest tightness, and shortness of breath
Important instructions
  • Primatene Mist is inhaled through the mouth via aerosol
  • Follow the dosing directions on the Primatene Mist package carefully
Available strengths 1 strength
125 mcg
4 FDA-listed product records ⓘ

Oral solution

By mouth
Available strengths 1 strength
9 [hp_X]/29.5 mL
2 FDA-listed product records ⓘ

Topical solution

Dental · Periodontal · Subgingival
Brands Orostat 8%
Available strengths 1 strength
1200 mg/15 mL
2 FDA-listed product records ⓘ

📊 Epinephrine across the U.S. market

How Epinephrine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms ⓘ
68
Manufacturers
21
Brand names
275
FDA-listed product records ⓘ
1948
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (30) · Kit (8) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

HF Acquisition Co LLC, DBA HealthFirst12%
Medical Purchasing Solutions, LLC9%
Remedyrepack Inc.9%
A-S Medication Solutions7%
BPI Labs, LLC5%
Par Health USA, LLC5%
Other makers53%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Epinephrine is used

A general measure of how commonly Epinephrine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Epinephrine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,108,898
Medicaid prescriptions filled (Q1–Q4 2025)
$291.7M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Epinephrine prescribed? Of the 1,596 medications we measure, Epinephrine ranks #158 by Medicaid prescriptions — more than 90% of them.

Where Epinephrine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #158 of 1,596
#153 Medroxyprogesterone 1,134,727 Rx #154 Azelastine Nasal Spray 1,133,133 Rx #155 Paroxetine 1,132,136 Rx #156 Promethazine 1,115,560 Rx #157 Norethindrone 1,115,474 Rx #158 Epinephrine 1,108,898 Rx #159 Clotrimazole 1,108,672 Rx #160 Ezetimibe 1,107,588 Rx #161 Epinephrine Injection 1,101,355 Rx #162 Clobetasol 1,099,263 Rx #163 Lithium 1,098,757 Rx

Utilization by Epinephrine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.3 mL / 1 mg/mL auto-injector is the most-dispensed Epinephrine product — about 46% of these Medicaid prescriptions.

NDA019430 0.3 ML epinephrine 1 MG/ML Auto-Injector Most dispensed

509,986 Medicaid prescriptions (Q1–Q4 2025) 46% of Epinephrine prescriptions shown $142.9M gross reimbursement (before rebates) ≈ $280 per prescription (gross)

Summed across the 3 of 15 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1870207

NDA020800 0.3 ML epinephrine 1 MG/ML Auto-Injector

283,234 Medicaid prescriptions (Q1–Q4 2025) 26% of Epinephrine prescriptions shown $51.1M gross reimbursement (before rebates) ≈ $180 per prescription (gross)

Summed across the 1 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1870230

NDA019430 0.3 ML epinephrine 0.5 MG/ML Auto-Injector

240,125 Medicaid prescriptions (Q1–Q4 2025) 22% of Epinephrine prescriptions shown $68.6M gross reimbursement (before rebates) ≈ $286 per prescription (gross)

Summed across the 3 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 727316

NDA020800 0.15 ML epinephrine 1 MG/ML Auto-Injector

23,549 Medicaid prescriptions (Q1–Q4 2025) 2% of Epinephrine prescriptions shown $5.3M gross reimbursement (before rebates) ≈ $224 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1870225

NDA201739 0.3 ML epinephrine 1 MG/ML Auto-Injector

16,223 Medicaid prescriptions (Q1–Q4 2025) 1% of Epinephrine prescriptions shown $8.7M gross reimbursement (before rebates) ≈ $537 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1870205

1 ML epinephrine 1 MG/ML Injection

10,949 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $1M gross reimbursement (before rebates) ≈ $93 per prescription (gross)

Summed across the 3 of 55 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1660014

epinephrine 20 MG/ML Nasal Spray

6,503 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $5.2M gross reimbursement (before rebates) ≈ $805 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2693442

NDA201739 0.15 ML epinephrine 1 MG/ML Auto-Injector

6,113 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $3.6M gross reimbursement (before rebates) ≈ $582 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1870232

NDA201739 0.1 ML epinephrine 1 MG/ML Auto-Injector

5,830 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $3.9M gross reimbursement (before rebates) ≈ $676 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1991328

epinephrine 1 MG/ML Injectable Solution

3,883 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $358,973 gross reimbursement (before rebates) ≈ $92 per prescription (gross)

Summed across the 5 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310132

10 ML epinephrine 0.1 MG/ML Prefilled Syringe

1,463 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine prescriptions shown $96,403 gross reimbursement (before rebates) ≈ $66 per prescription (gross)

Summed across the 1 of 21 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 727373

epinephrine 10 MG/ML Nasal Spray

1,040 Medicaid prescriptions (Q2–Q4 2025) <1% of Epinephrine prescriptions shown $913,302 gross reimbursement (before rebates) ≈ $878 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2709207

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Epinephrine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 22 of 177 listed Epinephrine NDCs with Medicaid activity.

🔍 Compare Epinephrine products

A representative set of FDA-listed product records for Epinephrine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 275 products — FDA National Drug Code Directory. See every product, package size and price: browse all 275 Epinephrine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Epinephrine RxCUI 3992 10 dose forms · 32 strengths
  2. Dose form (SCDF) Inhalation Powder RxCUI 2108366 No current FDA listing
    Clinical drug / strength (SCD) 0.22 MG RxCUI 1546217
  3. Dose form (SCDF) Inhalation Solution RxCUI 2108382 No current FDA listing
  4. Dose form (SCDF) Injectable Solution RxCUI 372030 In current FDA listings
    Clinical drug / strength (SCD) 0.1 MG/ML RxCUI 310116 0.5 MG/ML RxCUI 245317 1 MG/ML RxCUI 310132
  6. Dose form (SCDF) Metered Dose Inhaler RxCUI 746206 In current FDA listings
    Clinical drug / strength (SCD) 160 ACTUAT epinephrine 0.125 MG/ACTUAT RxCUI 2109083 270 ACTUAT epinephrine 0.22 MG/ACTUAT RxCUI 883806
  7. Dose form (SCDF) Nasal Solution RxCUI 372031 In current FDA listings
    Clinical drug / strength (SCD) 1 MG/ML RxCUI 313967
  8. Dose form (SCDF) Nasal Spray RxCUI 2693441 In current FDA listings
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 2709207 20 MG/ML RxCUI 2693442
  9. Dose form (SCDF) Ophthalmic Solution RxCUI 372029 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG/ML RxCUI 106779 1 MG/ML RxCUI 244284 2.5 MG/ML RxCUI 310127 5 MG/ML RxCUI 106780 10 MG/ML RxCUI 141848
  10. Dose form (SCDF) Prefilled Syringe RxCUI 727310 No current FDA listing
    Clinical drug / strength (SCD) 0.3 ML epinephrine 0.5 MG/ML RxCUI 2178790 0.3 ML epinephrine 1 MG/ML RxCUI 1989112 1 ML epinephrine 1 MG/ML RxCUI 2637533 10 ML epinephrine 0.1 MG/ML RxCUI 727373

Look up RxCUI 3992 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Auvi-Q Adrenalin Symjepi Primatene Mist Inhaler neffy Epipen Adrenalinum Primatene Mist Epipen Jr Orostat 8% Epinephrine Professional EMS Epinephrine Convenience Kit Epinephrine 0.3 Adults Certa Dose Epinephrine Convenience Kit Epinephrine Pediatrics EpinephrineSnap-EMS

🏭 Manufacturers & labelers

HF Acquisition Co LLC, DBA HealthFirst 29 Medical Purchasing Solutions, LLC 22 Remedyrepack Inc. 22 A-S Medication Solutions 17 BPI Labs, LLC 12 Par Health USA, LLC 11 kaleo, Inc 9 Mylan Specialty L.P. 8 Par Pharmaceutical, Inc. 8 Amneal Pharmaceuticals of New York LLC 6 Baxter Healthcare Corporation 6 International Medication Systems, Limited 5 Henry Schein, Inc. 5 Professional Compounding Centers of America dba PCCA 5 Sina Health Inc 5 Asclemed USA, Inc. 4 Boiron 4 Teva Pharmaceuticals USA, Inc. 4 Armstrong Pharmaceuticals, Inc. 4 Viatris Specialty LLC 4 Fresenius Kabi USA, LLC 4 Sportpharm LLC 4 Gland Pharma Limited 3 ProPharma Distribution 3

…and 16 more on the FDA NDC directory.

RxNorm drug class

Epinephrine belongs to the alpha-Adrenergic Agonist class.

Pharmacologic class alpha-Adrenergic Agonist, beta-Adrenergic Agonist, Catecholamine
Drug family (ATC) Other agents for local oral treatment, Local hemostatics, Adrenergic and dopaminergic agents
How it works Adrenergic alpha-Agonists, Adrenergic beta-Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Feb 15, 2023
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Epinephrine.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Epinephrine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
88
NDC products indexed
275
Distinct labelers/manufacturers represented
68
Linked representative label ⓘ
Mylan Specialty L.P.
Linked label effective
Feb 15, 2023
Composite sections available
20
Linked SPL Set ID
778ac6ae-6bcb-47a4-bcb3-8dd0da9f8836
Linked SPL Document ID
b526b53a-fe41-462e-b453-745f36d136eb
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 88 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Mylan Specialty L.P. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.