Esketamine Nasal Spray

194 interactions 98 cited references

Also sold as: Spravato Spravato®

About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene

1 Contraindicated 183 Major 10 Moderate

All (194) Contraindicated (1) Major (183) Moderate (10)

Major

Esketamine Nasal Spray Levocetirizine Xyzal Increased risk of CNS depression Details Esketamine Nasal Spray Levodopa Inbrija An increased risk of CNS depression Details Esketamine Nasal Spray Levorphanol Xyvona Increased risk of sedation Details Esketamine Nasal Spray Lomitapide Increased lomitapide exposure Details Esketamine Nasal Spray Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Esketamine Nasal Spray Lorazepam Ativan Increased risk of sedation Details Esketamine Nasal Spray Loxapine Adasuve Increased risk of sedation Details Esketamine Nasal Spray Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Esketamine Nasal Spray Meclizine Antivert Increased risk of sedation Details Esketamine Nasal Spray Melperone Increased risk of sedation Details Esketamine Nasal Spray Meperidine Demerol Increased risk of sedation Details Esketamine Nasal Spray Mephobarbital Increased risk of sedation Details Esketamine Nasal Spray Meprobamate Increased risk of sedation Details Esketamine Nasal Spray Meptazinol Increased risk of sedation Details Esketamine Nasal Spray Mesoridazine Increased risk of sedation Details Esketamine Nasal Spray Metaxalone Skelaxin Increased risk of sedation Details Esketamine Nasal Spray Methadone Diskets Increased risk of sedation Details Esketamine Nasal Spray Methdilazine Increased risk of sedation Details Esketamine Nasal Spray Methocarbamol Atmeksi Increased risk of sedation Details Esketamine Nasal Spray Methohexital Brevital Increased risk of sedation Details Esketamine Nasal Spray Methotrimeprazine Increased risk of sedation Details Esketamine Nasal Spray Methylene Blue Provayblue Increased risk of sedation Details Esketamine Nasal Spray Methylergonovine Methergine Increased methylergonovine exposure Details Esketamine Nasal Spray Midazolam Increased risk of sedation Details Esketamine Nasal Spray Mifepristone Korlym Increased miFEPRIStone exposure Details Esketamine Nasal Spray Molindone Increased risk of sedation Details Esketamine Nasal Spray Moricizine Increased risk of sedation Details Esketamine Nasal Spray Morphine Increased risk of sedation Details Esketamine Nasal Spray Morphine Sulfate Liposome Increased risk of sedation Details Esketamine Nasal Spray Nalbuphine Increased risk of sedation Details Esketamine Nasal Spray Nicomorphine Increased risk of sedation Details Esketamine Nasal Spray Nifedipine Adalat® Increased NIFEdipine exposure Details Esketamine Nasal Spray Nitrazepam Increased risk of sedation Details Esketamine Nasal Spray Nitrous Oxide Increased risk of sedation Details Esketamine Nasal Spray Olanzapine Increased risk of sedation Details Esketamine Nasal Spray Oliceridine Olinvyk An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Esketamine Nasal Spray Opium Increased risk of sedation Details Esketamine Nasal Spray Opium Alkaloids Increased risk of sedation Details Esketamine Nasal Spray Orphenadrine Increased risk of sedation Details Esketamine Nasal Spray Oxazepam Increased risk of sedation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.