Esketamine Nasal Spray

194 interactions 98 cited references

Also sold as: Spravato Spravato®

About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene

1 Contraindicated 183 Major 10 Moderate

All (194) Contraindicated (1) Major (183) Moderate (10)

Major

Esketamine Nasal Spray Oxycodone Oxaydo An increased risk of respiratory depression, profound sedation, coma and death Details Esketamine Nasal Spray Oxymorphone Increased risk of sedation Details Esketamine Nasal Spray Paliperidone Erzofri An increased risk of CNS depression Details Esketamine Nasal Spray Papaveretum Increased risk of sedation Details Esketamine Nasal Spray Paregoric Increased risk of sedation Details Esketamine Nasal Spray Pentazocine Increased risk of sedation Details Esketamine Nasal Spray Pentobarbital Fatal-Plus Increased risk of sedation Details Esketamine Nasal Spray Perampanel FYCOMPA Increased risk of sedation Details Esketamine Nasal Spray Perazine Increased risk of sedation Details Esketamine Nasal Spray Periciazine Increased risk of sedation Details Esketamine Nasal Spray Perphenazine Increased risk of sedation Details Esketamine Nasal Spray Phenobarbital Fidoquel Increased risk of sedation Details Esketamine Nasal Spray Pimozide Increased pimozide exposure and an increased risk of CNS depression Details Esketamine Nasal Spray Piperacetazine Increased risk of sedation Details Esketamine Nasal Spray Pipotiazine Increased risk of sedation Details Esketamine Nasal Spray Piritramide Increased risk of sedation Details Esketamine Nasal Spray Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Esketamine Nasal Spray Prazepam Increased risk of sedation Details Esketamine Nasal Spray Pregabalin Bonqat An increased risk of respiratory depression Details Esketamine Nasal Spray Primidone Mysoline Increased risk of sedation Details Esketamine Nasal Spray Prochlorperazine Increased risk of sedation Details Esketamine Nasal Spray Promazine Increased risk of sedation Details Esketamine Nasal Spray Promethazine Phenadoz Increased risk of sedation Details Esketamine Nasal Spray Propofol Diprivan Increased risk of sedation Details Esketamine Nasal Spray Quazepam Doral Increased risk of sedation Details Esketamine Nasal Spray Quetiapine Seroquel Increased risk of sedation Details Esketamine Nasal Spray Ramelteon Rozerem Increased risk of sedation Details Esketamine Nasal Spray Remifentanil Increased risk of sedation Details Esketamine Nasal Spray Remimazolam Byfavo Increased risk of profound sedation, respiratory depression, coma, and death Details Esketamine Nasal Spray Remoxipride Increased risk of sedation Details Esketamine Nasal Spray Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Esketamine Nasal Spray Ropeginterferon Alfa-2B-Njft Besremi Increased risk of sedation Details Esketamine Nasal Spray Scopolamine Pamine Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Esketamine Nasal Spray Secobarbital Increased risk of sedation Details Esketamine Nasal Spray Sertindole Increased risk of sedation Details Esketamine Nasal Spray Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Esketamine Nasal Spray Sufentanil Dsuvia Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Esketamine Nasal Spray Sulpiride Increased risk of sedation Details Esketamine Nasal Spray Suvorexant Belsomra Increased risk of sedation Details Esketamine Nasal Spray Tapentadol Nucynta Increased risk of sedation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.