Esketamine Nasal Spray

194 interactions 98 cited references
Also sold as: Spravato Spravato®
About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene
1 Contraindicated 183 Major 10 Moderate
All (194) Contraindicated (1) Major (183) Moderate (10)

Major

Esketamine Nasal Spray Temazepam Restoril Increased risk of sedation Details Esketamine Nasal Spray Thiethylperazine Increased risk of sedation Details Esketamine Nasal Spray Thiopental Increased risk of sedation Details Esketamine Nasal Spray Thiopropazate Increased risk of sedation Details Esketamine Nasal Spray Thioridazine Increased risk of sedation Details Esketamine Nasal Spray Tilidine Increased risk of sedation Details Esketamine Nasal Spray Tizanidine Increased risk of sedation Details Esketamine Nasal Spray Tolonium Chloride Increased risk of sedation Details Esketamine Nasal Spray Topiramate Eprontia Increased risk of sedation Details Esketamine Nasal Spray Tramadol ConZip Increased traMADol exposure, an increased risk of CNS depression and an increased risk of seizures, serotonin syndrome and opioid... Details Esketamine Nasal Spray Tranylcypromine Parnate An increased risk of CNS depression Details Esketamine Nasal Spray Trazodone Raldesy Increased risk of CNS depression Details Esketamine Nasal Spray Triazolam Halcion Increased risk of sedation Details Esketamine Nasal Spray Trifluoperazine Increased risk of sedation Details Esketamine Nasal Spray Trifluperidol Increased risk of sedation Details Esketamine Nasal Spray Triflupromazine Increased risk of sedation Details Esketamine Nasal Spray Trimeprazine Increased risk of sedation Details Esketamine Nasal Spray Voriconazole Vfend Increased voriconazole exposure and an increased risk of voriconazole-related adverse reaction Details Esketamine Nasal Spray Zaleplon Increased risk of sedation Details Esketamine Nasal Spray Ziprasidone Geodon An increased risk of CNS depression Details Esketamine Nasal Spray Zolpidem Ambien Increased risk of sedation Details Esketamine Nasal Spray Zopiclone Increased risk of sedation Details Esketamine Nasal Spray Zotepine Increased risk of sedation Details Esketamine Nasal Spray Zuranolone Zurzuvae An increased risk of CNS depression Details

Moderate

Esketamine Nasal Spray Artemether Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Esketamine Nasal Spray Brimonidine Alphagan An increased risk of CNS depression Details Esketamine Nasal Spray Carbachol Isopto Carbachol An increased risk of CNS depression Details Esketamine Nasal Spray Clonidine Duraclon An increased risk of sedation and somnolence Details Esketamine Nasal Spray Dofetilide Tikosyn Increased dofetilide exposure Details Esketamine Nasal Spray Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Esketamine Nasal Spray Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Esketamine Nasal Spray Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Esketamine Nasal Spray Sparsentan Filspari Reduced CYP2B6 substrate exposure and reduced efficacy of CYP2B6 substrate Details Esketamine Nasal Spray Thiotepa Tepadina Increased CYP2B6 substrates exposure Details

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