Fluorouracil

90 interactions 816 cited references

Also sold as: Adrucil Carac Efudex Favlyxa Fluoroplex Tolak

Read the full Fluorouracil drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Brivudine Mumps Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Measles Virus Vaccine, Live Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live

11 Contraindicated 73 Major 4 Moderate 2 Minor

All (90) Contraindicated (11) Major (73) Moderate (4) Minor (2)

Contraindicated

Fluorouracil Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Brivudine Increased exposure of 5-fluorouracil Details Fluorouracil Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Fluorouracil Tegafur Increased antineoplastic toxicity Details Fluorouracil Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Fluorouracil Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Fluorouracil Abrocitinib Cibinqo Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Fluorouracil Allopurinol Injection Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Fluorouracil Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Benznidazole Increased exposure of 5-fluorouracil Details Fluorouracil Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Diclofenac Ophthalmic Voltaren® Eye Drops Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Diclofenac Topical (Actinic Keratosis) Pennsaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Diclofenac Topical (Arthritis Pain) Pennsaid® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Diclofenac Transdermal Patch Flector Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Acenocoumarol Increased vitamin K antagonist exposure and an increased risk of bleeding Details Fluorouracil Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Fluorouracil Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Fluorouracil Azanidazole Increased exposure of 5-fluorouracil Details Fluorouracil Carvedilol Coreg Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Celecoxib Celebrex Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects Details Fluorouracil Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Fluorouracil Cimetidine Tagamet An increased risk of fluorouracil toxicity Details Fluorouracil Diclofenac Aleve Arthritis Pain Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Etrasimod Velsipity Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Etravirine Intelence Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Fluorouracil Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details

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