Fostemsavir

240 interactions 263 cited references

Also sold as: Rukobia Rukobia®

About Fostemsavir

Fostemsavir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults whose HIV could not be successfully treated with other medications, including their current therapy. Fostemsavir is in a class of medications called HIV attachment inhibitors. It works by decreasing the amou… Read the full Fostemsavir drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fosphenytoin Grazoprevir Mitotane Phenytoin Ivosidenib Lumacaftor

22 Contraindicated 208 Major 10 Moderate

All (240) Contraindicated (22) Major (208) Moderate (10)

Contraindicated

Fostemsavir Apalutamide Erleada Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Bepridil An increased risk of QT interval prolongation Details Fostemsavir Carbamazepine Carbatrol Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Cisapride Propulsid® Increased risk of QT interval prolongation Details Fostemsavir Dronedarone Multaq Increased risk of QT interval prolongation Details Fostemsavir Elagolix Orilissa Increased elagolix exposure and an increased risk of elagolix-related adverse reactions Details Fostemsavir Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Fostemsavir Enzalutamide Xtandi Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Fosphenytoin Cerebyx Reduced temsavir exposure, possible loss of virologic response and an increased risk of QT interval prolongation Details Fostemsavir Grazoprevir Increased grazoprevir exposure and increased risk of ALT elevations Details Fostemsavir Ivosidenib Tibsovo Reduced temsavir exposure and possible loss of virologic response and increased risk of QT interval prolongation Details Fostemsavir Lumacaftor Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Mitotane Lysodren Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Phenytoin Dilantin Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Piperaquine An increased risk of QT interval prolongation Details Fostemsavir Rifampin Rifadin Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Rifapentine Priftin Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Saquinavir An increased risk of QT interval prolongation Details Fostemsavir Sparfloxacin An increased risk of QT interval prolongation Details Fostemsavir St John's Wort Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details Fostemsavir Terfenadine An increased risk of QT interval prolongation Details Fostemsavir Thioridazine An increased risk of QT interval prolongation Details

Major

Fostemsavir Amitriptyline Elavil Increased risk of torsade de pointes Details Fostemsavir Sertraline Increased risk of torsade de pointes Details Fostemsavir Buprenorphine Belbuca Increased risk of torsade de pointes Details Fostemsavir Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Fostemsavir Arsenic Trioxide Trisenox Increased risk of torsade de pointes Details Fostemsavir Aripiprazole Injection Abilify Increased risk of torsade de pointes Details Fostemsavir Arsenic Trioxide Injection Trisenox Increased risk of torsade de pointes Details Fostemsavir Asenapine Transdermal Patch Secuado Increased risk of torsade de pointes Details Fostemsavir Atogepant Qulipta Increased atogepant exposure Details Fostemsavir Azithromycin AzaSite Increased risk of torsade de pointes Details Fostemsavir Alfuzosin UroXatral Increased risk of torsade de pointes Details Fostemsavir Anagrelide Agrylin Increased risk of torsade de pointes Details Fostemsavir Bedaquiline Sirturo Increased risk of torsade de pointes Details Fostemsavir Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Fostemsavir Chloroquine Aralen® Increased risk of torsade de pointes Details Fostemsavir Dasatinib Phyrago Increased risk of torsade de pointes Details Fostemsavir Degarelix Injection Firmagon Increased risk of torsade de pointes Details Fostemsavir Deutetrabenazine Austedo Increased risk of torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.