Rosuvastatin and Fostemsavir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Rosuvastatin
Fostemsavir
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of the HMG-CoA reductase inhibitor
Interaction Deep Dive
After coadministration of a single 10-mg dose of rosuvastatin with fostemsavir 600 mg twice daily (N=18), rosuvastatin exposure increased significantly. Coadministration of fostemsavir with HMG-CoA reductase inhibitors (statins) may increase statin exposure; use the lowest possible starting dose for statins and monitor for statin-associated adverse events1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) After coadministration of a single 10-mg dose of rosuvastatin with fostemsavir 600 mg twice daily (N=18), rosuvastatin exposure increased significantly; mean rosuvastatin Cmax increased by 78% (90% CI, 52% to 109%) and mean AUC increased by 69% (90% CI, 44% to 99%) 1.
Common questions
Can I take Rosuvastatin and Fostemsavir together?
Increased exposure of the HMG-CoA reductase inhibitor Always confirm with your pharmacist or prescriber before making any change.
How serious is the Rosuvastatin and Fostemsavir interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Rosuvastatin or Fostemsavir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: RUKOBIA oral extended-release tablets, fostemsavir oral extended-release tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2020. DailyMed
Keep reading about Rosuvastatin
Keep reading about Fostemsavir
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