Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Butriptyline An increased risk of seizures Details Hydroxychloroquine Butylscopolamine An increased risk of seizures Details Hydroxychloroquine Calcium Carbonate Alka-Mints Reduced hydroxychloroquine exposure Details Hydroxychloroquine Calcium Silicate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Cannabidiol Epidiolex Impaired antiepileptic activity Details Hydroxychloroquine Carbamazepine Carbatrol Reduced carBAMazepine activity and an increased risk of seizures Details Hydroxychloroquine Carbenicillin An increased risk of seizures Details Hydroxychloroquine Carbinoxamine Carbzah An increased risk of seizures Details Hydroxychloroquine Cenobamate Xcopri Impaired antiepileptic activity Details Hydroxychloroquine Ceritinib Zykadia An increased risk of QT interval prolongation Details Hydroxychloroquine Chlorotrianisene An increased risk of seizures Details Hydroxychloroquine Chlorpheniramine An increased risk of seizures Details Hydroxychloroquine Chlorphenoxamine An increased risk of seizures Details Hydroxychloroquine Chlorpromazine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Chlorpropamide Diabinese® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Chlorprothixene An increased risk of seizures Details Hydroxychloroquine Cimetidine Tagamet Increased hydroxychloroquine exposure Details Hydroxychloroquine Cimetropium An increased risk of seizures Details Hydroxychloroquine Cinnarizine An increased risk of seizures Details Hydroxychloroquine Ciprofloxacin An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Citalopram Celexa An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Clarithromycin Biaxin Increased risk of QT interval prolongation Details Hydroxychloroquine Clemastine Clemasz An increased risk of seizures Details Hydroxychloroquine Clemizole An increased risk of seizures Details Hydroxychloroquine Clidinium An increased risk of seizures Details Hydroxychloroquine Clobazam Onfi Impaired antiepileptic activity Details Hydroxychloroquine Clofazimine An increased risk of QT interval prolongation Details Hydroxychloroquine Clomipramine Anafranil Increased clomiPRAMINE exposure, an increased risk of QT interval prolongation, an increased risk of seizure Details Hydroxychloroquine Clonazepam Klonopin Impaired antiepileptic activity Details Hydroxychloroquine Clorazepate Dipotassium Impaired antiepileptic activity Details Hydroxychloroquine Clothiapine Increased risk of cardiac arrhythmia and an increased risk of seizures Details Hydroxychloroquine Clovoxamine An increased risk of seizures Details Hydroxychloroquine Cloxacillin An increased risk of seizures Details Hydroxychloroquine Clozapine Clozaril Increased risk of QT interval prolongation Details Hydroxychloroquine Cocaine Goprelto An increased risk of seizures Details Hydroxychloroquine Conjugated / Estrogens Premarin An increased risk of seizures Details Hydroxychloroquine Crizotinib Xalkori Increased risk of QT interval prolongation Details Hydroxychloroquine Cyclacillin An increased risk of seizures Details Hydroxychloroquine Cyclizine An increased risk of seizures Details Hydroxychloroquine Cyclobenzaprine Amrix Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.